The gamble between oncolytic virus therapy and IFN

Various studies are being conducted on oncolytic virotherapy which one of the mechanisms is mediating interferon (IFN) production by it exerts antitumor effects. The antiviral effect of IFN itself has a negative impact on the inhibition of oncolytic virus or tumor eradication. Therefore, it is very...

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Autores principales: Li, Qingbo, Tan, Fengxian, Wang, Yuanyuan, Liu, Xiaohui, Kong, Xianbin, Meng, Jingyan, Yang, Long, Cen, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453641/
https://www.ncbi.nlm.nih.gov/pubmed/36090998
http://dx.doi.org/10.3389/fimmu.2022.971674
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author Li, Qingbo
Tan, Fengxian
Wang, Yuanyuan
Liu, Xiaohui
Kong, Xianbin
Meng, Jingyan
Yang, Long
Cen, Shan
author_facet Li, Qingbo
Tan, Fengxian
Wang, Yuanyuan
Liu, Xiaohui
Kong, Xianbin
Meng, Jingyan
Yang, Long
Cen, Shan
author_sort Li, Qingbo
collection PubMed
description Various studies are being conducted on oncolytic virotherapy which one of the mechanisms is mediating interferon (IFN) production by it exerts antitumor effects. The antiviral effect of IFN itself has a negative impact on the inhibition of oncolytic virus or tumor eradication. Therefore, it is very critical to understand the mechanism of IFN regulation by oncolytic viruses, and to define its mechanism is of great significance for improving the antitumor effect of oncolytic viruses. This review focuses on the regulatory mechanisms of IFNs by various oncolytic viruses and their combination therapies. In addition, the exerting and the producing pathways of IFNs are briefly summarized, and some current issues are put forward.
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spelling pubmed-94536412022-09-09 The gamble between oncolytic virus therapy and IFN Li, Qingbo Tan, Fengxian Wang, Yuanyuan Liu, Xiaohui Kong, Xianbin Meng, Jingyan Yang, Long Cen, Shan Front Immunol Immunology Various studies are being conducted on oncolytic virotherapy which one of the mechanisms is mediating interferon (IFN) production by it exerts antitumor effects. The antiviral effect of IFN itself has a negative impact on the inhibition of oncolytic virus or tumor eradication. Therefore, it is very critical to understand the mechanism of IFN regulation by oncolytic viruses, and to define its mechanism is of great significance for improving the antitumor effect of oncolytic viruses. This review focuses on the regulatory mechanisms of IFNs by various oncolytic viruses and their combination therapies. In addition, the exerting and the producing pathways of IFNs are briefly summarized, and some current issues are put forward. Frontiers Media S.A. 2022-08-25 /pmc/articles/PMC9453641/ /pubmed/36090998 http://dx.doi.org/10.3389/fimmu.2022.971674 Text en Copyright © 2022 Li, Tan, Wang, Liu, Kong, Meng, Yang and Cen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Li, Qingbo
Tan, Fengxian
Wang, Yuanyuan
Liu, Xiaohui
Kong, Xianbin
Meng, Jingyan
Yang, Long
Cen, Shan
The gamble between oncolytic virus therapy and IFN
title The gamble between oncolytic virus therapy and IFN
title_full The gamble between oncolytic virus therapy and IFN
title_fullStr The gamble between oncolytic virus therapy and IFN
title_full_unstemmed The gamble between oncolytic virus therapy and IFN
title_short The gamble between oncolytic virus therapy and IFN
title_sort gamble between oncolytic virus therapy and ifn
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453641/
https://www.ncbi.nlm.nih.gov/pubmed/36090998
http://dx.doi.org/10.3389/fimmu.2022.971674
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