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The altered functional connectivity density related to cognitive impairment in alcoholics

Alcohol use disorder (AUD) is one of the most common substance use disorders contributing to both behavioral and cognitive impairments in patients with AUD. Recent neuroimaging studies point out that AUD is a typical disorder featured by altered functional connectivity. However, the details about ho...

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Autores principales: Duan, Ranran, Li, Yanfei, Jing, Lijun, Zhang, Tian, Yao, Yaobing, Gong, Zhe, Shao, Yingzhe, Song, Yajun, Wang, Weijian, Zhang, Yong, Cheng, Jingliang, Zhu, Xiaofeng, Peng, Ying, Jia, Yanjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453650/
https://www.ncbi.nlm.nih.gov/pubmed/36092050
http://dx.doi.org/10.3389/fpsyg.2022.973654
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author Duan, Ranran
Li, Yanfei
Jing, Lijun
Zhang, Tian
Yao, Yaobing
Gong, Zhe
Shao, Yingzhe
Song, Yajun
Wang, Weijian
Zhang, Yong
Cheng, Jingliang
Zhu, Xiaofeng
Peng, Ying
Jia, Yanjie
author_facet Duan, Ranran
Li, Yanfei
Jing, Lijun
Zhang, Tian
Yao, Yaobing
Gong, Zhe
Shao, Yingzhe
Song, Yajun
Wang, Weijian
Zhang, Yong
Cheng, Jingliang
Zhu, Xiaofeng
Peng, Ying
Jia, Yanjie
author_sort Duan, Ranran
collection PubMed
description Alcohol use disorder (AUD) is one of the most common substance use disorders contributing to both behavioral and cognitive impairments in patients with AUD. Recent neuroimaging studies point out that AUD is a typical disorder featured by altered functional connectivity. However, the details about how voxel-wise functional coordination remain unknown. Here, we adopted a newly proposed method named functional connectivity density (FCD) to depict altered voxel-wise functional coordination in AUD. The novel functional imaging technique, FCD, provides a comprehensive analytical method for brain's “scale-free” networks. We applied resting-state functional MRI (rs-fMRI) toward subjects to obtain their FCD, including global FCD (gFCD), local FCD (lFCD), and long-range FCD (lrFCD). Sixty-one patients with AUD and 29 healthy controls (HC) were recruited, and patients with AUD were further divided into alcohol-related cognitive impairment group (ARCI, n = 11) and non-cognitive impairment group (AUD-NCI, n = 50). All subjects were asked to stay stationary during the scan in order to calculate the resting-state gFCD, lFCD, and lrFCD values, and further investigate the abnormal connectivity alterations among AUD-NCI, ARCI, and HC. Compared to HC, both AUD groups exhibited significantly altered gFCD in the left inferior occipital lobe, left calcarine, altered lFCD in right lingual, and altered lrFCD in ventromedial frontal gyrus (VMPFC). It is notable that gFCD of the ARCI group was found to be significantly deviated from AUD-NCI and HC in left medial frontal gyrus, which changes probably contributed by the impairment in cognition. In addition, no significant differences in gFCD were found between ARCI and HC in left parahippocampal, while ARCI and HC were profoundly deviated from AUD-NCI, possibly reflecting a compensation of cognition impairment. Further analysis showed that within patients with AUD, gFCD values in left medial frontal gyrus are negatively correlated with MMSE scores, while lFCD values in left inferior occipital lobe are positively related to ADS scores. In conclusion, patients with AUD exhibited significantly altered functional connectivity patterns mainly in several left hemisphere brain regions, while patients with AUD with or without cognitive impairment also demonstrated intergroup FCD differences which correlated with symptom severity, and patients with AUD cognitive impairment would suffer less severe alcohol dependence. This difference in symptom severity probably served as a compensation for cognitive impairment, suggesting a difference in pathological pathways. These findings assisted future AUD studies by providing insight into possible pathological mechanisms.
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spelling pubmed-94536502022-09-09 The altered functional connectivity density related to cognitive impairment in alcoholics Duan, Ranran Li, Yanfei Jing, Lijun Zhang, Tian Yao, Yaobing Gong, Zhe Shao, Yingzhe Song, Yajun Wang, Weijian Zhang, Yong Cheng, Jingliang Zhu, Xiaofeng Peng, Ying Jia, Yanjie Front Psychol Psychology Alcohol use disorder (AUD) is one of the most common substance use disorders contributing to both behavioral and cognitive impairments in patients with AUD. Recent neuroimaging studies point out that AUD is a typical disorder featured by altered functional connectivity. However, the details about how voxel-wise functional coordination remain unknown. Here, we adopted a newly proposed method named functional connectivity density (FCD) to depict altered voxel-wise functional coordination in AUD. The novel functional imaging technique, FCD, provides a comprehensive analytical method for brain's “scale-free” networks. We applied resting-state functional MRI (rs-fMRI) toward subjects to obtain their FCD, including global FCD (gFCD), local FCD (lFCD), and long-range FCD (lrFCD). Sixty-one patients with AUD and 29 healthy controls (HC) were recruited, and patients with AUD were further divided into alcohol-related cognitive impairment group (ARCI, n = 11) and non-cognitive impairment group (AUD-NCI, n = 50). All subjects were asked to stay stationary during the scan in order to calculate the resting-state gFCD, lFCD, and lrFCD values, and further investigate the abnormal connectivity alterations among AUD-NCI, ARCI, and HC. Compared to HC, both AUD groups exhibited significantly altered gFCD in the left inferior occipital lobe, left calcarine, altered lFCD in right lingual, and altered lrFCD in ventromedial frontal gyrus (VMPFC). It is notable that gFCD of the ARCI group was found to be significantly deviated from AUD-NCI and HC in left medial frontal gyrus, which changes probably contributed by the impairment in cognition. In addition, no significant differences in gFCD were found between ARCI and HC in left parahippocampal, while ARCI and HC were profoundly deviated from AUD-NCI, possibly reflecting a compensation of cognition impairment. Further analysis showed that within patients with AUD, gFCD values in left medial frontal gyrus are negatively correlated with MMSE scores, while lFCD values in left inferior occipital lobe are positively related to ADS scores. In conclusion, patients with AUD exhibited significantly altered functional connectivity patterns mainly in several left hemisphere brain regions, while patients with AUD with or without cognitive impairment also demonstrated intergroup FCD differences which correlated with symptom severity, and patients with AUD cognitive impairment would suffer less severe alcohol dependence. This difference in symptom severity probably served as a compensation for cognitive impairment, suggesting a difference in pathological pathways. These findings assisted future AUD studies by providing insight into possible pathological mechanisms. Frontiers Media S.A. 2022-08-25 /pmc/articles/PMC9453650/ /pubmed/36092050 http://dx.doi.org/10.3389/fpsyg.2022.973654 Text en Copyright © 2022 Duan, Li, Jing, Zhang, Yao, Gong, Shao, Song, Wang, Zhang, Cheng, Zhu, Peng and Jia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Duan, Ranran
Li, Yanfei
Jing, Lijun
Zhang, Tian
Yao, Yaobing
Gong, Zhe
Shao, Yingzhe
Song, Yajun
Wang, Weijian
Zhang, Yong
Cheng, Jingliang
Zhu, Xiaofeng
Peng, Ying
Jia, Yanjie
The altered functional connectivity density related to cognitive impairment in alcoholics
title The altered functional connectivity density related to cognitive impairment in alcoholics
title_full The altered functional connectivity density related to cognitive impairment in alcoholics
title_fullStr The altered functional connectivity density related to cognitive impairment in alcoholics
title_full_unstemmed The altered functional connectivity density related to cognitive impairment in alcoholics
title_short The altered functional connectivity density related to cognitive impairment in alcoholics
title_sort altered functional connectivity density related to cognitive impairment in alcoholics
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453650/
https://www.ncbi.nlm.nih.gov/pubmed/36092050
http://dx.doi.org/10.3389/fpsyg.2022.973654
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