Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro

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In addition to its essential role in viral polyprotein processing, the SARS-CoV-2 3C-like protease (3CLpro) can cleave human immune signaling proteins, like NF-κB Essential Modulator (NEMO) and deregulate the host immune response. Here, in vitro assays show that SARS-CoV-2 3CLpro cleaves NEMO with f...

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Detalles Bibliográficos
Autores principales: Hameedi, Mikhail A., T. Prates, Erica, Garvin, Michael R., Mathews, Irimpan I., Amos, B. Kirtley, Demerdash, Omar, Bechthold, Mark, Iyer, Mamta, Rahighi, Simin, Kneller, Daniel W., Kovalevsky, Andrey, Irle, Stephan, Vuong, Van-Quan, Mitchell, Julie C., Labbe, Audrey, Galanie, Stephanie, Wakatsuki, Soichi, Jacobson, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453703/
https://www.ncbi.nlm.nih.gov/pubmed/36075915
http://dx.doi.org/10.1038/s41467-022-32922-9
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