Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments

Metal–organic framework (MOF) coatings on cells enhance viability in cytotoxic environments. Here, we show how protective multi-layered MOF bio-composite shells on a model cell system (yeast) enhance the proliferation of living cells exposed to hostile protease-rich environments via the dissolution...

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Detalles Bibliográficos
Autores principales: Gan, Lei, Velásquez-Hernández, Miriam de J., Emmerstorfer-Augustin, Anita, Wied, Peter, Wolinski, Heimo, Zilio, Simone Dal, Solomon, Marcello, Liang, Weibin, Doonan, Christian, Falcaro, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453912/
https://www.ncbi.nlm.nih.gov/pubmed/35942713
http://dx.doi.org/10.1039/d2cc03072a
Descripción
Sumario:Metal–organic framework (MOF) coatings on cells enhance viability in cytotoxic environments. Here, we show how protective multi-layered MOF bio-composite shells on a model cell system (yeast) enhance the proliferation of living cells exposed to hostile protease-rich environments via the dissolution of the shells and release of a protease inhibitor (antitrypsin).

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