Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments

Metal–organic framework (MOF) coatings on cells enhance viability in cytotoxic environments. Here, we show how protective multi-layered MOF bio-composite shells on a model cell system (yeast) enhance the proliferation of living cells exposed to hostile protease-rich environments via the dissolution...

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Detalles Bibliográficos
Autores principales: Gan, Lei, Velásquez-Hernández, Miriam de J., Emmerstorfer-Augustin, Anita, Wied, Peter, Wolinski, Heimo, Zilio, Simone Dal, Solomon, Marcello, Liang, Weibin, Doonan, Christian, Falcaro, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453912/
https://www.ncbi.nlm.nih.gov/pubmed/35942713
http://dx.doi.org/10.1039/d2cc03072a
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author Gan, Lei
Velásquez-Hernández, Miriam de J.
Emmerstorfer-Augustin, Anita
Wied, Peter
Wolinski, Heimo
Zilio, Simone Dal
Solomon, Marcello
Liang, Weibin
Doonan, Christian
Falcaro, Paolo
author_facet Gan, Lei
Velásquez-Hernández, Miriam de J.
Emmerstorfer-Augustin, Anita
Wied, Peter
Wolinski, Heimo
Zilio, Simone Dal
Solomon, Marcello
Liang, Weibin
Doonan, Christian
Falcaro, Paolo
author_sort Gan, Lei
collection PubMed
description Metal–organic framework (MOF) coatings on cells enhance viability in cytotoxic environments. Here, we show how protective multi-layered MOF bio-composite shells on a model cell system (yeast) enhance the proliferation of living cells exposed to hostile protease-rich environments via the dissolution of the shells and release of a protease inhibitor (antitrypsin).
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spelling pubmed-94539122022-10-04 Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments Gan, Lei Velásquez-Hernández, Miriam de J. Emmerstorfer-Augustin, Anita Wied, Peter Wolinski, Heimo Zilio, Simone Dal Solomon, Marcello Liang, Weibin Doonan, Christian Falcaro, Paolo Chem Commun (Camb) Chemistry Metal–organic framework (MOF) coatings on cells enhance viability in cytotoxic environments. Here, we show how protective multi-layered MOF bio-composite shells on a model cell system (yeast) enhance the proliferation of living cells exposed to hostile protease-rich environments via the dissolution of the shells and release of a protease inhibitor (antitrypsin). The Royal Society of Chemistry 2022-08-01 /pmc/articles/PMC9453912/ /pubmed/35942713 http://dx.doi.org/10.1039/d2cc03072a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Gan, Lei
Velásquez-Hernández, Miriam de J.
Emmerstorfer-Augustin, Anita
Wied, Peter
Wolinski, Heimo
Zilio, Simone Dal
Solomon, Marcello
Liang, Weibin
Doonan, Christian
Falcaro, Paolo
Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments
title Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments
title_full Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments
title_fullStr Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments
title_full_unstemmed Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments
title_short Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments
title_sort multi-layered zif-coated cells for the release of bioactive molecules in hostile environments
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453912/
https://www.ncbi.nlm.nih.gov/pubmed/35942713
http://dx.doi.org/10.1039/d2cc03072a
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