Cargando…

National cohort of infants born before 24 gestational weeks showed increased survival rates but no improvement in neonatal morbidity

AIM: To describe survival and neonatal morbidities in infants born before 24 weeks of gestation during a 12‐year period. METHODS: Data were retrieved from national registries and validated in medical files of infants born before 24 weeks of gestation 2007–2018 in Sweden. Temporal changes were evalua...

Descripción completa

Detalles Bibliográficos
Autores principales: Lundgren, Pia, Morsing, Eva, Hård, Anna‐Lena, Rakow, Alexander, Hellström‐Westas, Lena, Jacobson, Lena, Johnson, Mats, Holmström, Gerd, Nilsson, Staffan, Smith, Lois E., Sävman, Karin, Hellström, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454067/
https://www.ncbi.nlm.nih.gov/pubmed/35395120
http://dx.doi.org/10.1111/apa.16354
_version_ 1784785271501357056
author Lundgren, Pia
Morsing, Eva
Hård, Anna‐Lena
Rakow, Alexander
Hellström‐Westas, Lena
Jacobson, Lena
Johnson, Mats
Holmström, Gerd
Nilsson, Staffan
Smith, Lois E.
Sävman, Karin
Hellström, Ann
author_facet Lundgren, Pia
Morsing, Eva
Hård, Anna‐Lena
Rakow, Alexander
Hellström‐Westas, Lena
Jacobson, Lena
Johnson, Mats
Holmström, Gerd
Nilsson, Staffan
Smith, Lois E.
Sävman, Karin
Hellström, Ann
author_sort Lundgren, Pia
collection PubMed
description AIM: To describe survival and neonatal morbidities in infants born before 24 weeks of gestation during a 12‐year period. METHODS: Data were retrieved from national registries and validated in medical files of infants born before 24 weeks of gestation 2007–2018 in Sweden. Temporal changes were evaluated. RESULTS: In 2007–2018, 282 live births were recorded at 22 weeks and 460 at 23 weeks of gestation. Survival to discharge from hospital of infants born alive at 22 and 23 weeks increased from 20% to 38% (p = 0.006) and from 45% to 67% (p < 0.001) respectively. Caesarean section increased from 12% to 22% (p = 0.038) for infants born at 22 weeks. Neonatal morbidity rates in infants alive at 40 weeks of postmenstrual age (n = 399) were unchanged except for an increase in necrotising enterocolitis from 0 to 33% (p = 0.017) in infants born at 22 weeks of gestation. Bronchopulmonary dysplasia was more common in boys than girls, 90% versus 82% (p = 0.044). The number of infants surviving to 40 weeks doubled over time. CONCLUSION: Increased survival of infants born before 24 weeks of gestation resulted in increasing numbers of very immature infants with severe neonatal morbidities likely to have a negative impact on long‐term outcome.
format Online
Article
Text
id pubmed-9454067
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-94540672022-09-08 National cohort of infants born before 24 gestational weeks showed increased survival rates but no improvement in neonatal morbidity Lundgren, Pia Morsing, Eva Hård, Anna‐Lena Rakow, Alexander Hellström‐Westas, Lena Jacobson, Lena Johnson, Mats Holmström, Gerd Nilsson, Staffan Smith, Lois E. Sävman, Karin Hellström, Ann Acta Paediatr Original Articles & Brief Reports AIM: To describe survival and neonatal morbidities in infants born before 24 weeks of gestation during a 12‐year period. METHODS: Data were retrieved from national registries and validated in medical files of infants born before 24 weeks of gestation 2007–2018 in Sweden. Temporal changes were evaluated. RESULTS: In 2007–2018, 282 live births were recorded at 22 weeks and 460 at 23 weeks of gestation. Survival to discharge from hospital of infants born alive at 22 and 23 weeks increased from 20% to 38% (p = 0.006) and from 45% to 67% (p < 0.001) respectively. Caesarean section increased from 12% to 22% (p = 0.038) for infants born at 22 weeks. Neonatal morbidity rates in infants alive at 40 weeks of postmenstrual age (n = 399) were unchanged except for an increase in necrotising enterocolitis from 0 to 33% (p = 0.017) in infants born at 22 weeks of gestation. Bronchopulmonary dysplasia was more common in boys than girls, 90% versus 82% (p = 0.044). The number of infants surviving to 40 weeks doubled over time. CONCLUSION: Increased survival of infants born before 24 weeks of gestation resulted in increasing numbers of very immature infants with severe neonatal morbidities likely to have a negative impact on long‐term outcome. John Wiley and Sons Inc. 2022-04-12 2022-08 /pmc/articles/PMC9454067/ /pubmed/35395120 http://dx.doi.org/10.1111/apa.16354 Text en © 2022 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles & Brief Reports
Lundgren, Pia
Morsing, Eva
Hård, Anna‐Lena
Rakow, Alexander
Hellström‐Westas, Lena
Jacobson, Lena
Johnson, Mats
Holmström, Gerd
Nilsson, Staffan
Smith, Lois E.
Sävman, Karin
Hellström, Ann
National cohort of infants born before 24 gestational weeks showed increased survival rates but no improvement in neonatal morbidity
title National cohort of infants born before 24 gestational weeks showed increased survival rates but no improvement in neonatal morbidity
title_full National cohort of infants born before 24 gestational weeks showed increased survival rates but no improvement in neonatal morbidity
title_fullStr National cohort of infants born before 24 gestational weeks showed increased survival rates but no improvement in neonatal morbidity
title_full_unstemmed National cohort of infants born before 24 gestational weeks showed increased survival rates but no improvement in neonatal morbidity
title_short National cohort of infants born before 24 gestational weeks showed increased survival rates but no improvement in neonatal morbidity
title_sort national cohort of infants born before 24 gestational weeks showed increased survival rates but no improvement in neonatal morbidity
topic Original Articles & Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454067/
https://www.ncbi.nlm.nih.gov/pubmed/35395120
http://dx.doi.org/10.1111/apa.16354
work_keys_str_mv AT lundgrenpia nationalcohortofinfantsbornbefore24gestationalweeksshowedincreasedsurvivalratesbutnoimprovementinneonatalmorbidity
AT morsingeva nationalcohortofinfantsbornbefore24gestationalweeksshowedincreasedsurvivalratesbutnoimprovementinneonatalmorbidity
AT hardannalena nationalcohortofinfantsbornbefore24gestationalweeksshowedincreasedsurvivalratesbutnoimprovementinneonatalmorbidity
AT rakowalexander nationalcohortofinfantsbornbefore24gestationalweeksshowedincreasedsurvivalratesbutnoimprovementinneonatalmorbidity
AT hellstromwestaslena nationalcohortofinfantsbornbefore24gestationalweeksshowedincreasedsurvivalratesbutnoimprovementinneonatalmorbidity
AT jacobsonlena nationalcohortofinfantsbornbefore24gestationalweeksshowedincreasedsurvivalratesbutnoimprovementinneonatalmorbidity
AT johnsonmats nationalcohortofinfantsbornbefore24gestationalweeksshowedincreasedsurvivalratesbutnoimprovementinneonatalmorbidity
AT holmstromgerd nationalcohortofinfantsbornbefore24gestationalweeksshowedincreasedsurvivalratesbutnoimprovementinneonatalmorbidity
AT nilssonstaffan nationalcohortofinfantsbornbefore24gestationalweeksshowedincreasedsurvivalratesbutnoimprovementinneonatalmorbidity
AT smithloise nationalcohortofinfantsbornbefore24gestationalweeksshowedincreasedsurvivalratesbutnoimprovementinneonatalmorbidity
AT savmankarin nationalcohortofinfantsbornbefore24gestationalweeksshowedincreasedsurvivalratesbutnoimprovementinneonatalmorbidity
AT hellstromann nationalcohortofinfantsbornbefore24gestationalweeksshowedincreasedsurvivalratesbutnoimprovementinneonatalmorbidity