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Evasion of interferon-mediated immune response by arteriviruses
IFN is the most potent antiviral cytokine required for the innate and adaptive immune responses, and its expression can help the host defend against viral infection. Arteriviruses have evolved strategies to antagonize the host cell’s innate immune responses, interfering with IFN expression by interf...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454096/ https://www.ncbi.nlm.nih.gov/pubmed/36091073 http://dx.doi.org/10.3389/fimmu.2022.963923 |
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author | Jian, Zhijie Ma, Rui Zhu, Ling Deng, Huidan Li, Fengqin Zhao, Jun Deng, Lishuang Lai, Siyuan Sun, Xiangang Tang, Huaqiao Xu, Zhiwen |
author_facet | Jian, Zhijie Ma, Rui Zhu, Ling Deng, Huidan Li, Fengqin Zhao, Jun Deng, Lishuang Lai, Siyuan Sun, Xiangang Tang, Huaqiao Xu, Zhiwen |
author_sort | Jian, Zhijie |
collection | PubMed |
description | IFN is the most potent antiviral cytokine required for the innate and adaptive immune responses, and its expression can help the host defend against viral infection. Arteriviruses have evolved strategies to antagonize the host cell’s innate immune responses, interfering with IFN expression by interfering with RIG, blocking PRR, obstructing IRF-3/7, NF-κB, and degrading STAT1 signaling pathways, thereby assisting viral immune evasion. Arteriviruses infect immune cells and may result in persistence in infected hosts. In this article, we reviewed the strategies used by Arteriviruses to antagonize IFN production and thwart IFN-activated antiviral signaling, mainly including structural and nonstructural proteins of Arteriviruses encoding IFN antagonists directly or indirectly to disrupt innate immunity. This review will certainly provide a better insight into the pathogenesis of the arthritis virus and provide a theoretical basis for developing more efficient vaccines. |
format | Online Article Text |
id | pubmed-9454096 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94540962022-09-09 Evasion of interferon-mediated immune response by arteriviruses Jian, Zhijie Ma, Rui Zhu, Ling Deng, Huidan Li, Fengqin Zhao, Jun Deng, Lishuang Lai, Siyuan Sun, Xiangang Tang, Huaqiao Xu, Zhiwen Front Immunol Immunology IFN is the most potent antiviral cytokine required for the innate and adaptive immune responses, and its expression can help the host defend against viral infection. Arteriviruses have evolved strategies to antagonize the host cell’s innate immune responses, interfering with IFN expression by interfering with RIG, blocking PRR, obstructing IRF-3/7, NF-κB, and degrading STAT1 signaling pathways, thereby assisting viral immune evasion. Arteriviruses infect immune cells and may result in persistence in infected hosts. In this article, we reviewed the strategies used by Arteriviruses to antagonize IFN production and thwart IFN-activated antiviral signaling, mainly including structural and nonstructural proteins of Arteriviruses encoding IFN antagonists directly or indirectly to disrupt innate immunity. This review will certainly provide a better insight into the pathogenesis of the arthritis virus and provide a theoretical basis for developing more efficient vaccines. Frontiers Media S.A. 2022-08-15 /pmc/articles/PMC9454096/ /pubmed/36091073 http://dx.doi.org/10.3389/fimmu.2022.963923 Text en Copyright © 2022 Jian, Ma, Zhu, Deng, Li, Zhao, Deng, Lai, Sun, Tang and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Jian, Zhijie Ma, Rui Zhu, Ling Deng, Huidan Li, Fengqin Zhao, Jun Deng, Lishuang Lai, Siyuan Sun, Xiangang Tang, Huaqiao Xu, Zhiwen Evasion of interferon-mediated immune response by arteriviruses |
title | Evasion of interferon-mediated immune response by arteriviruses |
title_full | Evasion of interferon-mediated immune response by arteriviruses |
title_fullStr | Evasion of interferon-mediated immune response by arteriviruses |
title_full_unstemmed | Evasion of interferon-mediated immune response by arteriviruses |
title_short | Evasion of interferon-mediated immune response by arteriviruses |
title_sort | evasion of interferon-mediated immune response by arteriviruses |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454096/ https://www.ncbi.nlm.nih.gov/pubmed/36091073 http://dx.doi.org/10.3389/fimmu.2022.963923 |
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