N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates

[Image: see text] Parkinson’s disease is associated with the aberrant aggregation of α-synuclein. Although the causes of this process are still unclear, post-translational modifications of α-synuclein are likely to play a modulatory role. Since α-synuclein is constitutively N-terminally acetylated,...

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Detalles Bibliográficos
Autores principales: Bell, Rosie, Thrush, Rebecca J., Castellana-Cruz, Marta, Oeller, Marc, Staats, Roxine, Nene, Aishwarya, Flagmeier, Patrick, Xu, Catherine K., Satapathy, Sandeep, Galvagnion, Celine, Wilson, Mark R., Dobson, Christopher M., Kumita, Janet R., Vendruscolo, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454101/
https://www.ncbi.nlm.nih.gov/pubmed/35944093
http://dx.doi.org/10.1021/acs.biochem.2c00104

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