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Targeting RNA N(6)-methyladenosine modification: a precise weapon in overcoming tumor immune escape
Immunotherapy, especially immune checkpoint inhibitors (ICIs), has revolutionized the treatment of many types of cancer, particularly advanced-stage cancers. Nevertheless, although a subset of patients experiences dramatic and long-term disease regression in response to ICIs, most patients do not be...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454167/ https://www.ncbi.nlm.nih.gov/pubmed/36071523 http://dx.doi.org/10.1186/s12943-022-01652-3 |
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author | Li, Wei Hao, Yi Zhang, Xingda Xu, Shouping Pang, Da |
author_facet | Li, Wei Hao, Yi Zhang, Xingda Xu, Shouping Pang, Da |
author_sort | Li, Wei |
collection | PubMed |
description | Immunotherapy, especially immune checkpoint inhibitors (ICIs), has revolutionized the treatment of many types of cancer, particularly advanced-stage cancers. Nevertheless, although a subset of patients experiences dramatic and long-term disease regression in response to ICIs, most patients do not benefit from these treatments. Some may even experience cancer progression. Immune escape by tumor cells may be a key reason for this low response rate. N(6)-methyladenosine (m(6)A) is the most common type of RNA methylation and has been recognized as a critical regulator of tumors and the immune system. Therefore, m(6)A modification and related regulators are promising targets for improving the efficacy of tumor immunotherapy. However, the association between m(6)A modification and tumor immune escape (TIE) has not been comprehensively summarized. Therefore, this review summarizes the existing knowledge regarding m(6)A modifications involved in TIE and their potential mechanisms of action. Moreover, we provide an overview of currently available agents targeting m(6)A regulators that have been tested for their elevated effects on TIE. This review establishes the association between m(6)A modifications and TIE and provides new insights and strategies for maximizing the efficacy of immunotherapy by specifically targeting m(6)A modifications involved in TIE. |
format | Online Article Text |
id | pubmed-9454167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-94541672022-09-09 Targeting RNA N(6)-methyladenosine modification: a precise weapon in overcoming tumor immune escape Li, Wei Hao, Yi Zhang, Xingda Xu, Shouping Pang, Da Mol Cancer Review Immunotherapy, especially immune checkpoint inhibitors (ICIs), has revolutionized the treatment of many types of cancer, particularly advanced-stage cancers. Nevertheless, although a subset of patients experiences dramatic and long-term disease regression in response to ICIs, most patients do not benefit from these treatments. Some may even experience cancer progression. Immune escape by tumor cells may be a key reason for this low response rate. N(6)-methyladenosine (m(6)A) is the most common type of RNA methylation and has been recognized as a critical regulator of tumors and the immune system. Therefore, m(6)A modification and related regulators are promising targets for improving the efficacy of tumor immunotherapy. However, the association between m(6)A modification and tumor immune escape (TIE) has not been comprehensively summarized. Therefore, this review summarizes the existing knowledge regarding m(6)A modifications involved in TIE and their potential mechanisms of action. Moreover, we provide an overview of currently available agents targeting m(6)A regulators that have been tested for their elevated effects on TIE. This review establishes the association between m(6)A modifications and TIE and provides new insights and strategies for maximizing the efficacy of immunotherapy by specifically targeting m(6)A modifications involved in TIE. BioMed Central 2022-09-07 /pmc/articles/PMC9454167/ /pubmed/36071523 http://dx.doi.org/10.1186/s12943-022-01652-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Li, Wei Hao, Yi Zhang, Xingda Xu, Shouping Pang, Da Targeting RNA N(6)-methyladenosine modification: a precise weapon in overcoming tumor immune escape |
title | Targeting RNA N(6)-methyladenosine modification: a precise weapon in overcoming tumor immune escape |
title_full | Targeting RNA N(6)-methyladenosine modification: a precise weapon in overcoming tumor immune escape |
title_fullStr | Targeting RNA N(6)-methyladenosine modification: a precise weapon in overcoming tumor immune escape |
title_full_unstemmed | Targeting RNA N(6)-methyladenosine modification: a precise weapon in overcoming tumor immune escape |
title_short | Targeting RNA N(6)-methyladenosine modification: a precise weapon in overcoming tumor immune escape |
title_sort | targeting rna n(6)-methyladenosine modification: a precise weapon in overcoming tumor immune escape |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454167/ https://www.ncbi.nlm.nih.gov/pubmed/36071523 http://dx.doi.org/10.1186/s12943-022-01652-3 |
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