The highly conserved RNA-binding specificity of nucleocapsid protein facilitates the identification of drugs with broad anti-coronavirus activity

The binding of SARS-CoV-2 nucleocapsid (N) protein to both the 5′- and 3′-ends of genomic RNA has different implications arising from its binding to the central region during virion assembly. However, the mechanism underlying selective binding remains unknown. Herein, we performed the high-throughpu...

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Detalles Bibliográficos
Autores principales: Fan, Shaorong, Sun, Wenju, Fan, Ligang, Wu, Nan, Sun, Wei, Ma, Haiqian, Chen, Siyuan, Li, Zitong, Li, Yu, Zhang, Jilin, Yan, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454191/
https://www.ncbi.nlm.nih.gov/pubmed/36097552
http://dx.doi.org/10.1016/j.csbj.2022.09.007

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