Cargando…

Epigenetic clock indicates accelerated aging in glial cells of progressive multiple sclerosis patients

BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease of the central nervous system (CNS) characterized by irreversible disability at later progressive stages. A growing body of evidence suggests that disease progression depends on age and inflammation within the CN...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kular, Lara, Klose, Dennis, Urdánoz-Casado, Amaya, Ewing, Ewoud, Planell, Nuria, Gomez-Cabrero, David, Needhamsen, Maria, Jagodic, Maja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454196/ https://www.ncbi.nlm.nih.gov/pubmed/36092807 http://dx.doi.org/10.3389/fnagi.2022.926468

Ejemplares similares

DNA methylation changes in glial cells of the normal-appearing white matter in Multiple Sclerosis patients
por: Kular, Lara, et al.
Publicado: (2022)

Usability of human Infinium MethylationEPIC BeadChip for mouse DNA methylation studies
por: Needhamsen, Maria, et al.
Publicado: (2017)

GeneSetCluster: a tool for summarizing and integrating gene-set analysis results
por: Ewing, Ewoud, et al.
Publicado: (2020)

Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis
por: Kular, Lara, et al.
Publicado: (2019)

Simultaneous detection of DNA variation and methylation at HLA class II locus and immune gene promoters using targeted SureSelect Methyl-Sequencing
por: Kalomoiri, Maria, et al.
Publicado: (2023)

Evaluation of Cell-Specific Epigenetic Age Acceleration in People With Multiple Sclerosis
por: Maltby, Vicki, et al.
Publicado: (2023)

Combining evidence from four immune cell types identifies DNA methylation patterns that implicate functionally distinct pathways during Multiple Sclerosis progression
por: Ewing, Ewoud, et al.
Publicado: (2019)

Methylome and transcriptome signature of bronchoalveolar cells from multiple sclerosis patients in relation to smoking
por: Ringh, Mikael V, et al.
Publicado: (2020)

Non-parametric combination analysis of multiple data types enables detection of novel regulatory mechanisms in T cells of multiple sclerosis patients
por: Fernandes, Sunjay Jude, et al.
Publicado: (2019)

Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells
por: Lund, Harald, et al.
Publicado: (2018)

STATegra: Multi-Omics Data Integration – A Conceptual Scheme With a Bioinformatics Pipeline
por: Planell, Nuria, et al.
Publicado: (2021)

Hypermethylation of MIR21 in CD4+ T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes
por: Ruhrmann, Sabrina, et al.
Publicado: (2017)

Epigenetic Alterations Associated With Early Prenatal Dexamethasone Treatment
por: Karlsson, Leif, et al.
Publicado: (2018)

Integration of small RNAs from plasma and cerebrospinal fluid for classification of multiple sclerosis
por: Needhamsen, Maria, et al.
Publicado: (2022)

Epigenetic Clocks Are Not Accelerated in COVID-19 Patients
por: Franzen, Julia, et al.
Publicado: (2021)

DNA Methylation Signatures of Multiple Sclerosis Occur Independently of Known Genetic Risk and Are Primarily Attributed to B Cells and Monocytes
por: Xavier, Alexandre, et al.
Publicado: (2023)

Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes
por: Carlström, Karl E., et al.
Publicado: (2019)

NXN Gene Epigenetic Changes in an Adult Neurogenesis Model of Alzheimer’s Disease
por: Blanco-Luquin, Idoia, et al.
Publicado: (2022)

Perturbed epigenetic transcriptional regulation in AML with IDH mutations causes increased susceptibility to NK cells
por: Palau, Anna, et al.
Publicado: (2023)

HIV-1 Infection Accelerates Age According to the Epigenetic Clock
por: Horvath, Steve, et al.
Publicado: (2015)

Systematic underestimation of the epigenetic clock and age acceleration in older subjects
por: El Khoury, Louis Y., et al.
Publicado: (2019)

PLD3 epigenetic changes in the hippocampus of Alzheimer’s disease
por: Blanco-Luquin, Idoia, et al.
Publicado: (2018)

Tobacco smoking induces changes in true DNA methylation, hydroxymethylation and gene expression in bronchoalveolar lavage cells
por: Ringh, Mikael V., et al.
Publicado: (2019)

Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship
por: Marabita, Francesco, et al.
Publicado: (2017)

Liquid biopsy: a new source of candidate biomarkers in amyotrophic lateral sclerosis
por: Mendioroz, Maite, et al.
Publicado: (2018)

Author Correction: Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship
por: Marabita, Francesco, et al.
Publicado: (2018)

Longitudinal DNA methylation changes at MET may alter HGF/c-MET signalling in adolescents at risk for depression
por: Ciuculete, Diana M., et al.
Publicado: (2019)

Comparison of EM-seq and PBAT methylome library methods for low-input DNA
por: Han, Yanan, et al.
Publicado: (2021)

Epigenetic clocks galore: a new improved clock predicts age-acceleration in Hutchinson Gilford Progeria Syndrome patients
por: Teschendorff, Andrew E.
Publicado: (2018)

Epigenetic clock and methylation studies in elephants
por: Prado, Natalia A., et al.
Publicado: (2021)

DNA methylation accelerated age as captured by epigenetic clocks influences breast cancer risk
por: Valencia, Celina I., et al.
Publicado: (2023)

Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder
por: Baldelli, Luca, et al.
Publicado: (2023)

Developmental Tuning of Epigenetic Clock
por: Vaiserman, Alexander
Publicado: (2018)

An evolutionary epigenetic clock in plants
por: Yao, N, et al.
Publicado: (2023)

Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis
por: Carlström, Karl E., et al.
Publicado: (2020)

Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity
por: Dec, Eric, et al.
Publicado: (2023)

Small noncoding RNA profiling across cellular and biofluid compartments and their implications for multiple sclerosis immunopathology
por: Zheleznyakova, Galina Yurevna, et al.
Publicado: (2021)

Neuronal and Glial Clocks Underlying Structural Remodeling of Pacemaker Neurons in Drosophila
por: Herrero, Anastasia, et al.
Publicado: (2017)

DNA methylation age at birth and childhood: performance of epigenetic clocks and characteristics associated with epigenetic age acceleration in the Project Viva cohort
por: Bozack, Anne K., et al.
Publicado: (2023)

Common threads: epigenetics, metabolism and the clock
por: Sassone-Corsi, Paolo
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_r4a86fhvk2j0e4at1krefc5bkh