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A Case of Adult-Onset IgA Vasculitis in a Cirrhotic Patient
Immunoglobulin A vasculitis (IgAV; formerly called Henoch-Schönlein purpura) is a disease commonly seen in children as an immune reaction after a viral infection. It is a small vessel vasculitis characterized by immune complex deposits in various organs throughout the body. It mainly affects the ski...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454305/ https://www.ncbi.nlm.nih.gov/pubmed/36106304 http://dx.doi.org/10.7759/cureus.27812 |
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author | Bazigh, Izza Patel, Etee Khan, Uzair Ghalib, Neha Singh, Aaparna |
author_facet | Bazigh, Izza Patel, Etee Khan, Uzair Ghalib, Neha Singh, Aaparna |
author_sort | Bazigh, Izza |
collection | PubMed |
description | Immunoglobulin A vasculitis (IgAV; formerly called Henoch-Schönlein purpura) is a disease commonly seen in children as an immune reaction after a viral infection. It is a small vessel vasculitis characterized by immune complex deposits in various organs throughout the body. It mainly affects the skin, joints, abdomen and kidneys. This presentation is less likely to be seen in adults. In adults, IgAV can be seen due to decreased clearance of immune complexes through the liver. A damaged liver due to alcoholic liver cirrhosis can hinder the clearance of IgA complexes. We present an unusual case of a 42-year-old female who presented with alcoholic liver cirrhosis and ascites and later developed a purpuric rash in her lower extremities. |
format | Online Article Text |
id | pubmed-9454305 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-94543052022-09-13 A Case of Adult-Onset IgA Vasculitis in a Cirrhotic Patient Bazigh, Izza Patel, Etee Khan, Uzair Ghalib, Neha Singh, Aaparna Cureus Internal Medicine Immunoglobulin A vasculitis (IgAV; formerly called Henoch-Schönlein purpura) is a disease commonly seen in children as an immune reaction after a viral infection. It is a small vessel vasculitis characterized by immune complex deposits in various organs throughout the body. It mainly affects the skin, joints, abdomen and kidneys. This presentation is less likely to be seen in adults. In adults, IgAV can be seen due to decreased clearance of immune complexes through the liver. A damaged liver due to alcoholic liver cirrhosis can hinder the clearance of IgA complexes. We present an unusual case of a 42-year-old female who presented with alcoholic liver cirrhosis and ascites and later developed a purpuric rash in her lower extremities. Cureus 2022-08-09 /pmc/articles/PMC9454305/ /pubmed/36106304 http://dx.doi.org/10.7759/cureus.27812 Text en Copyright © 2022, Bazigh et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Bazigh, Izza Patel, Etee Khan, Uzair Ghalib, Neha Singh, Aaparna A Case of Adult-Onset IgA Vasculitis in a Cirrhotic Patient |
title | A Case of Adult-Onset IgA Vasculitis in a Cirrhotic Patient |
title_full | A Case of Adult-Onset IgA Vasculitis in a Cirrhotic Patient |
title_fullStr | A Case of Adult-Onset IgA Vasculitis in a Cirrhotic Patient |
title_full_unstemmed | A Case of Adult-Onset IgA Vasculitis in a Cirrhotic Patient |
title_short | A Case of Adult-Onset IgA Vasculitis in a Cirrhotic Patient |
title_sort | case of adult-onset iga vasculitis in a cirrhotic patient |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454305/ https://www.ncbi.nlm.nih.gov/pubmed/36106304 http://dx.doi.org/10.7759/cureus.27812 |
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