Clinicopathologic Features and Treatment of CD10-Positive Mantle Cell Lymphoma: A Case Report and Review of Literature

Mantle cell lymphoma (MCL) is a rare and aggressive non-Hodgkin’s B cell lymphoma characterized by the translocation t(11;14) (q13;32) and overexpression of CCND1. MCL is immunophenotypically identified as CD20(+), CD5(+), CyclinD1+, CD43(+), CD10(−), BCL6(−), and CD23(−). It is often distinguished...

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Detalles Bibliográficos
Autores principales: Hino, Christopher, Pham, Bryan, Gray, Austin L., Wang, Jun, Castillo, Dan Ran, Akhtari, Mojtaba, Liu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pathology and Oncology Archive
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454308/
https://www.ncbi.nlm.nih.gov/pubmed/36091937
http://dx.doi.org/10.3389/pore.2022.1610588
Descripción
Sumario:Mantle cell lymphoma (MCL) is a rare and aggressive non-Hodgkin’s B cell lymphoma characterized by the translocation t(11;14) (q13;32) and overexpression of CCND1. MCL is immunophenotypically identified as CD20(+), CD5(+), CyclinD1+, CD43(+), CD10(−), BCL6(−), and CD23(−). It is often distinguished from B cell lymphomas of germinal center cell origin by the absence of CD10 expression. Here we report the unique clinicopathologic features of a patient with CD10(+) MCL with gastrointestinal involvement and review current literature identifying this unique immunophenotype.

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