Clinicopathologic Features and Treatment of CD10-Positive Mantle Cell Lymphoma: A Case Report and Review of Literature

Mantle cell lymphoma (MCL) is a rare and aggressive non-Hodgkin’s B cell lymphoma characterized by the translocation t(11;14) (q13;32) and overexpression of CCND1. MCL is immunophenotypically identified as CD20(+), CD5(+), CyclinD1+, CD43(+), CD10(−), BCL6(−), and CD23(−). It is often distinguished...

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Autores principales: Hino, Christopher, Pham, Bryan, Gray, Austin L., Wang, Jun, Castillo, Dan Ran, Akhtari, Mojtaba, Liu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pathology and Oncology Archive
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454308/
https://www.ncbi.nlm.nih.gov/pubmed/36091937
http://dx.doi.org/10.3389/pore.2022.1610588
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author Hino, Christopher
Pham, Bryan
Gray, Austin L.
Wang, Jun
Castillo, Dan Ran
Akhtari, Mojtaba
Liu, Yan
author_facet Hino, Christopher
Pham, Bryan
Gray, Austin L.
Wang, Jun
Castillo, Dan Ran
Akhtari, Mojtaba
Liu, Yan
author_sort Hino, Christopher
collection PubMed
description Mantle cell lymphoma (MCL) is a rare and aggressive non-Hodgkin’s B cell lymphoma characterized by the translocation t(11;14) (q13;32) and overexpression of CCND1. MCL is immunophenotypically identified as CD20(+), CD5(+), CyclinD1+, CD43(+), CD10(−), BCL6(−), and CD23(−). It is often distinguished from B cell lymphomas of germinal center cell origin by the absence of CD10 expression. Here we report the unique clinicopathologic features of a patient with CD10(+) MCL with gastrointestinal involvement and review current literature identifying this unique immunophenotype.
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spelling pubmed-94543082022-09-09 Clinicopathologic Features and Treatment of CD10-Positive Mantle Cell Lymphoma: A Case Report and Review of Literature Hino, Christopher Pham, Bryan Gray, Austin L. Wang, Jun Castillo, Dan Ran Akhtari, Mojtaba Liu, Yan Pathol Oncol Res Pathology and Oncology Archive Mantle cell lymphoma (MCL) is a rare and aggressive non-Hodgkin’s B cell lymphoma characterized by the translocation t(11;14) (q13;32) and overexpression of CCND1. MCL is immunophenotypically identified as CD20(+), CD5(+), CyclinD1+, CD43(+), CD10(−), BCL6(−), and CD23(−). It is often distinguished from B cell lymphomas of germinal center cell origin by the absence of CD10 expression. Here we report the unique clinicopathologic features of a patient with CD10(+) MCL with gastrointestinal involvement and review current literature identifying this unique immunophenotype. Frontiers Media S.A. 2022-08-25 /pmc/articles/PMC9454308/ /pubmed/36091937 http://dx.doi.org/10.3389/pore.2022.1610588 Text en Copyright © 2022 Hino, Pham, Gray, Wang, Castillo, Akhtari and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pathology and Oncology Archive
Hino, Christopher
Pham, Bryan
Gray, Austin L.
Wang, Jun
Castillo, Dan Ran
Akhtari, Mojtaba
Liu, Yan
Clinicopathologic Features and Treatment of CD10-Positive Mantle Cell Lymphoma: A Case Report and Review of Literature
title Clinicopathologic Features and Treatment of CD10-Positive Mantle Cell Lymphoma: A Case Report and Review of Literature
title_full Clinicopathologic Features and Treatment of CD10-Positive Mantle Cell Lymphoma: A Case Report and Review of Literature
title_fullStr Clinicopathologic Features and Treatment of CD10-Positive Mantle Cell Lymphoma: A Case Report and Review of Literature
title_full_unstemmed Clinicopathologic Features and Treatment of CD10-Positive Mantle Cell Lymphoma: A Case Report and Review of Literature
title_short Clinicopathologic Features and Treatment of CD10-Positive Mantle Cell Lymphoma: A Case Report and Review of Literature
title_sort clinicopathologic features and treatment of cd10-positive mantle cell lymphoma: a case report and review of literature
topic Pathology and Oncology Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454308/
https://www.ncbi.nlm.nih.gov/pubmed/36091937
http://dx.doi.org/10.3389/pore.2022.1610588
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