In-silico probing of AML related RUNX1 cancer-associated missense mutations: Predicted relationships to DNA binding and drug interactions

The molecular consequences of cancer associated mutations in Acute myeloid leukemia (AML) linked factors are not very well understood. Here, we interrogated the COSMIC database for missense mutations associated with the RUNX1 protein, that is frequently mis-regulated in AML, where we sought to ident...

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Detalles Bibliográficos
Autores principales: Ullah, Hanif, Zhang, Baoyun, Sharma, Narendra Kumar, McCrea, Pierre D., Srivastava, Yogesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454315/
https://www.ncbi.nlm.nih.gov/pubmed/36090034
http://dx.doi.org/10.3389/fmolb.2022.981020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454315/
https://www.ncbi.nlm.nih.gov/pubmed/36090034
http://dx.doi.org/10.3389/fmolb.2022.981020

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