The role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the pathophysiology of psoriasis and systemic lupus erythematosus

Inflammation and atherogenic dyslipidaemia are often observed in skin diseases and represent an increased risk of cardiovascular disorders. Proprotein convertase subtilisin/kexin type 9 plays an important role in the regulation of serum low-density lipoprotein cholesterol levels. Its biological role...

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Autores principales: Frątczak, Aleksandra, Polak, Karina, Szczepanek, Michał, Lis-Święty, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2022
Materias:
Review Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454343/
https://www.ncbi.nlm.nih.gov/pubmed/36090718
http://dx.doi.org/10.5114/ada.2022.118919
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author Frątczak, Aleksandra
Polak, Karina
Szczepanek, Michał
Lis-Święty, Anna
author_facet Frątczak, Aleksandra
Polak, Karina
Szczepanek, Michał
Lis-Święty, Anna
author_sort Frątczak, Aleksandra
collection PubMed
description Inflammation and atherogenic dyslipidaemia are often observed in skin diseases and represent an increased risk of cardiovascular disorders. Proprotein convertase subtilisin/kexin type 9 plays an important role in the regulation of serum low-density lipoprotein cholesterol levels. Its biological role, however, seems to go much beyond the regulation of cholesterol metabolism. The article presents potential pathophysiological links between inflammatory process and lipid disorders based on the example of psoriasis and systemic lupus erythematosus.
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spelling pubmed-94543432022-09-10 The role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the pathophysiology of psoriasis and systemic lupus erythematosus Frątczak, Aleksandra Polak, Karina Szczepanek, Michał Lis-Święty, Anna Postepy Dermatol Alergol Review Paper Inflammation and atherogenic dyslipidaemia are often observed in skin diseases and represent an increased risk of cardiovascular disorders. Proprotein convertase subtilisin/kexin type 9 plays an important role in the regulation of serum low-density lipoprotein cholesterol levels. Its biological role, however, seems to go much beyond the regulation of cholesterol metabolism. The article presents potential pathophysiological links between inflammatory process and lipid disorders based on the example of psoriasis and systemic lupus erythematosus. Termedia Publishing House 2022-09-01 2022-08 /pmc/articles/PMC9454343/ /pubmed/36090718 http://dx.doi.org/10.5114/ada.2022.118919 Text en Copyright: © 2022 Termedia Sp. z o. o. https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Review Paper
Frątczak, Aleksandra
Polak, Karina
Szczepanek, Michał
Lis-Święty, Anna
The role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the pathophysiology of psoriasis and systemic lupus erythematosus
title The role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the pathophysiology of psoriasis and systemic lupus erythematosus
title_full The role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the pathophysiology of psoriasis and systemic lupus erythematosus
title_fullStr The role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the pathophysiology of psoriasis and systemic lupus erythematosus
title_full_unstemmed The role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the pathophysiology of psoriasis and systemic lupus erythematosus
title_short The role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the pathophysiology of psoriasis and systemic lupus erythematosus
title_sort role of proprotein convertase subtilisin/kexin type 9 (pcsk9) in the pathophysiology of psoriasis and systemic lupus erythematosus
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454343/
https://www.ncbi.nlm.nih.gov/pubmed/36090718
http://dx.doi.org/10.5114/ada.2022.118919
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