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Substitution of l-Tryptophan by α-Methyl-l-Tryptophan in (177)Lu-RM2 Results in (177)Lu-AMTG, a High-Affinity Gastrin-Releasing Peptide Receptor Ligand with Improved In Vivo Stability
Theranostic applications targeting the gastrin-releasing peptide receptor (GRPR) have shown promising results. When compared with other peptide ligands for radioligand therapy, the most often used GRPR ligand, DOTA-Pip(5)-d-Phe(6)-Gln(7)-Trp(8)-Ala(9)-Val(10)-Gly(11)-His(12)-Sta(13)-Leu(14)-NH(2) (R...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Society of Nuclear Medicine
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454457/ https://www.ncbi.nlm.nih.gov/pubmed/35027371 http://dx.doi.org/10.2967/jnumed.121.263323 |