Mutant p53 Depletion by Novel Inhibitors for HSP40/J-Domain Proteins Derived from the Natural Compound Plumbagin

SIMPLE SUMMARY: The tumor suppressor p53 is frequently mutated in human cancer. Accumulation of missense mutant p53 (mutp53) in tumors is crucial for malignant progression, and cancers are often addicted to oncogenic mutp53. However, strategies to deplete mutp53 have not yet been established. Recent...

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Detalles Bibliográficos
Autores principales: Alalem, Mohamed, Bhosale, Mrinalini, Ranjan, Atul, Yamamoto, Satomi, Kaida, Atsushi, Nishikawa, Shigeto, Parrales, Alejandro, Farooki, Sana, Anant, Shrikant, Padhye, Subhash, Iwakuma, Tomoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454493/
https://www.ncbi.nlm.nih.gov/pubmed/36077724
http://dx.doi.org/10.3390/cancers14174187

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