Cargando…

IRF4 as an Oncogenic Master Transcription Factor

SIMPLE SUMMARY: Master transcription factors regulate essential developmental processes and cellular maintenance that characterize cell identity. Many of them also serve as oncogenes when aberrantly expressed or activated. IRF4 is one of prime examples of oncogenic master transcription factors that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wong, Regina Wan Ju, Ong, Jolynn Zu Lin, Theardy, Madelaine Skolastika, Sanda, Takaomi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454692/ https://www.ncbi.nlm.nih.gov/pubmed/36077849 http://dx.doi.org/10.3390/cancers14174314

Ejemplares similares

IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma
por: Amanda, Stella, et al.
Publicado: (2022)

Targeting dual oncogenic machineries driven by TAL1 and PI3K-AKT pathways in T-cell acute lymphoblastic leukemia
por: Lim, Fang Qi, et al.
Publicado: (2022)

Targeting General Transcriptional Machinery as a Therapeutic Strategy for Adult T-Cell Leukemia
por: Wong, Regina Wan Ju, et al.
Publicado: (2018)

Shared and Distinct Functions of the Transcription Factors IRF4 and IRF8 in Myeloid Cell Development
por: Yamamoto, Michio, et al.
Publicado: (2011)

Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4
por: Campos Carrascosa, Lucia, et al.
Publicado: (2017)

Transcriptional reprogramming by mutated IRF4 in lymphoma
por: Schleussner, Nikolai, et al.
Publicado: (2023)

Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas
por: Feldman, Andrew L., et al.
Publicado: (2008)

Aberrant Activation of the GIMAP Enhancer by Oncogenic Transcription Factors in T-cell Acute Lymphoblastic Leukemia
por: Liau, Wei-Siang, et al.
Publicado: (2016)

IRF4 Mediates the Oncogenic Effects of STAT3 in Anaplastic Large Cell Lymphomas
por: Bandini, Cecilia, et al.
Publicado: (2018)

IRF2 is a master regulator of human keratinocyte stem cell fate
por: Mercado, Nicolas, et al.
Publicado: (2019)

An IRF1-IRF4 Toggle-Switch Controls Tolerogenic and Immunogenic Transcriptional Programming in Human Langerhans Cells
por: Davies, James, et al.
Publicado: (2021)

BATF-JUN is critical for IRF4-mediated transcription in T cells
por: Li, Peng, et al.
Publicado: (2012)

IRF2 Destabilizes Oncogenic KPNA2 to Modulate the Development of Osteosarcoma
por: Xia, Shuchi, et al.
Publicado: (2022)

The IRF family of transcription factors: Inception, impact and implications in oncogenesis
por: Yanai, Hideyuki, et al.
Publicado: (2012)

The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival
por: Ohguchi, Hiroto, et al.
Publicado: (2016)

Hypoxia‐inducible microRNA‐210 regulates the DIMT1‐IRF4 oncogenic axis in multiple myeloma
por: Ikeda, Sho, et al.
Publicado: (2017)

Comprehensive Computational Analysis of Honokiol Targets for Cell Cycle Inhibition and Immunotherapy in Metastatic Breast Cancer Stem Cells
por: Skolastika, Skolastika, et al.
Publicado: (2022)

SPOP targets the immune transcription factor IRF1 for proteasomal degradation
por: Schwartz, Irene, et al.
Publicado: (2023)

IRF4-Dependent and IRF4-Independent Pathways Contribute to DC Dysfunction in Lupus
por: Manni, Michela, et al.
Publicado: (2015)

Functionally Antagonistic Transcription Factors IRF1 and IRF2 Regulate the Transcription of the Dopamine Receptor D2 Gene Associated with Aggressive Behavior of Weaned Pigs
por: Zhao, Jing, et al.
Publicado: (2022)

Brd4 regulates NLRC4 inflammasome activation by facilitating IRF8-mediated transcription of Naips
por: Dong, Xingchen, et al.
Publicado: (2021)

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia
por: Mansour, Marc R., et al.
Publicado: (2018)

Phosphorylation of Microglial IRF5 and IRF4 by IRAK4 Regulates Inflammatory Responses to Ischemia
por: Ngwa, Conelius, et al.
Publicado: (2021)

MicroRNA-18a-5p functions as an oncogene by directly targeting IRF2 in lung cancer
por: Liang, Chen, et al.
Publicado: (2017)

Regulation of Lymphocyte Apoptosis by Interferon Regulatory Factor 4 (IRF-4)
por: Fanzo, Jessica C., et al.
Publicado: (2003)

Interferons and IRF/Stat transcription factors in the regulation of immunity, oncogenesis and bone remodeling
por: Taniguchi, T, et al.
Publicado: (2003)

The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity
por: Chevrier, Stéphane, et al.
Publicado: (2014)

Transcription Factor IRF4 Dysfunction Affects the Immunosuppressive Function of Treg Cells in Patients with Primary Immune Thrombocytopenia
por: Tang, Meiwen, et al.
Publicado: (2019)

Quality of TCR signaling encoded by differential enhancer affinities for the composite BATF-IRF4 transcription factor complex
por: Iwata, Arifumi, et al.
Publicado: (2017)

Specific enhancer selection by IRF3, IRF5 and IRF9 is determined by ISRE half-sites, 5′ and 3′ flanking bases, collaborating transcription factors and the chromatin environment in a combinatorial fashion
por: Csumita, Mária, et al.
Publicado: (2020)

Repression of interferon regulatory factor-4 (IRF4) hyperactivation restricts murine lupus
por: He, Shijun, et al.
Publicado: (2023)

Transcription factor IRF5 drives P2X4R(+)-reactive microglia gating neuropathic pain
por: Masuda, Takahiro, et al.
Publicado: (2014)

Co-Expression of the B-Cell Key Transcription Factors Blimp-1 and IRF4 Identifies Plasma Cells in the Pig
por: Villanueva-Hernández, Sonia, et al.
Publicado: (2022)

Suppression of FOXP3 expression by the AP-1 family transcription factor BATF3 requires partnering with IRF4
por: Arnold, Preston R., et al.
Publicado: (2022)

The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation
por: Carotta, Sebastian, et al.
Publicado: (2014)

IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype
por: Masuda, Takahiro, et al.
Publicado: (2012)

Promotion of BST2 expression by the transcription factor IRF6 affects the progression of endometriosis
por: Li, Jixin, et al.
Publicado: (2023)

Division of labor between IRF1 and IRF2 in regulating different stages of transcriptional activation in cellular antiviral activities
por: Ren, Gang, et al.
Publicado: (2015)

HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections
por: Sun, Lei, et al.
Publicado: (2017)

Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming
por: McDaniel, Margaret M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_mi4553iee04ig9pss67bucoul8