An FDA-Approved Antifungal, Ketoconazole, and Its Novel Derivative Suppress tGLI1-Mediated Breast Cancer Brain Metastasis by Inhibiting the DNA-Binding Activity of Brain Metastasis-Promoting Transcription Factor tGLI1

SIMPLE SUMMARY: Breast cancer is the most commonly diagnosed cancer in American women, and metastasis accounts for the majority of breast cancer-related deaths. The common metastatic sites for breast cancer includes the bones, lungs, brain, and liver. Breast cancer brain metastasis (BCBM) patients h...

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Detalles Bibliográficos
Autores principales: Doheny, Daniel, Manore, Sara, Sirkisoon, Sherona R., Zhu, Dongqin, Aguayo, Noah R., Harrison, Alexandria, Najjar, Mariana, Anguelov, Marlyn, Cox, Anderson O’Brien, Furdui, Cristina M., Watabe, Kounosuke, Hollis, Thomas, Thomas, Alexandra, Strowd, Roy, Lo, Hui-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454738/
https://www.ncbi.nlm.nih.gov/pubmed/36077791
http://dx.doi.org/10.3390/cancers14174256

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