Neuroprotective Effects of a Novel Demeclocycline Derivative Lacking Antibiotic Activity: From a Hit to a Promising Lead Compound

The antibiotic tetracycline demeclocycline (DMC) was recently reported to rescue α-synuclein (α-Syn) fibril-induced pathology. However, the antimicrobial activity of DMC precludes its potential use in long-term neuroprotective treatments. Here, we synthesized a doubly reduced DMC (DDMC) derivative w...

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Detalles Bibliográficos
Autores principales: Tomas-Grau, Rodrigo, González-Lizárraga, Florencia, Ploper, Diego, Avila, César L., Socías, Sergio B., Besnault, Pierre, Tourville, Aurore, Mella, Rosa M., Villacé, Patricia, Salado, Clarisa, Rose, Clémence, Seon-Méniel, Blandine, Brunel, Jean-Michel, Ferrié, Laurent, Raisman-Vozari, Rita, Michel, Patrick P., Figadère, Bruno, Chehín, Rosana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454755/
https://www.ncbi.nlm.nih.gov/pubmed/36078167
http://dx.doi.org/10.3390/cells11172759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454755/
https://www.ncbi.nlm.nih.gov/pubmed/36078167
http://dx.doi.org/10.3390/cells11172759

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