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Colorectal Cancer in Inflammatory Bowel Diseases: Epidemiology and Prevention: A Review
SIMPLE SUMMARY: Colorectal cancer (CRC) is one of the most serious potential complications of inflammatory bowel diseases (IBDs). The aging of patients affected by IBDs makes this issue a challenge that will increasingly be faced by clinicians in clinical practice, especially in light of the poorer...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454776/ https://www.ncbi.nlm.nih.gov/pubmed/36077786 http://dx.doi.org/10.3390/cancers14174254 |
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author | Marabotto, Elisa Kayali, Stefano Buccilli, Silvia Levo, Francesca Bodini, Giorgia Giannini, Edoardo G. Savarino, Vincenzo Savarino, Edoardo Vincenzo |
author_facet | Marabotto, Elisa Kayali, Stefano Buccilli, Silvia Levo, Francesca Bodini, Giorgia Giannini, Edoardo G. Savarino, Vincenzo Savarino, Edoardo Vincenzo |
author_sort | Marabotto, Elisa |
collection | PubMed |
description | SIMPLE SUMMARY: Colorectal cancer (CRC) is one of the most serious potential complications of inflammatory bowel diseases (IBDs). The aging of patients affected by IBDs makes this issue a challenge that will increasingly be faced by clinicians in clinical practice, especially in light of the poorer prognosis for CRC in this group of people when compared with the general population. In this review, we summarize the current epidemiology, risk factors and various prevention strategies proposed for CRC in patients with IBDs. ABSTRACT: Colorectal cancer (CRC) is currently the third most frequent form of malignancy and the second in terms of mortality. Inflammatory bowel diseases (IBDs) are recognized risk factors for this type of cancer. Despite a worldwide increase in the incidence of CRC, the risk of CRC-related death in IBD patients has declined over time, probably because of successful surveillance strategies, the use of more effective drugs in the management of remission and improved indications to colectomy. This notwithstanding, CRC 5-year survival in patients with IBD is poorer than in the general population. This review provides a summary of the epidemiological features, risk factors and various prevention strategies proposed for CRC in IBD patients. Moreover, there is a special focus on reporting and highlighting the various prevention strategies proposed by the most important international scientific societies, both in terms of chemoprevention and endoscopic surveillance. Indeed, in conducting the analysis, we have given attention to the current primary, secondary and tertiary prevention guidelines, attempting to emphasize unresolved research and clinical problems related to this topic in order to improve diagnostic strategies and management. |
format | Online Article Text |
id | pubmed-9454776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94547762022-09-09 Colorectal Cancer in Inflammatory Bowel Diseases: Epidemiology and Prevention: A Review Marabotto, Elisa Kayali, Stefano Buccilli, Silvia Levo, Francesca Bodini, Giorgia Giannini, Edoardo G. Savarino, Vincenzo Savarino, Edoardo Vincenzo Cancers (Basel) Review SIMPLE SUMMARY: Colorectal cancer (CRC) is one of the most serious potential complications of inflammatory bowel diseases (IBDs). The aging of patients affected by IBDs makes this issue a challenge that will increasingly be faced by clinicians in clinical practice, especially in light of the poorer prognosis for CRC in this group of people when compared with the general population. In this review, we summarize the current epidemiology, risk factors and various prevention strategies proposed for CRC in patients with IBDs. ABSTRACT: Colorectal cancer (CRC) is currently the third most frequent form of malignancy and the second in terms of mortality. Inflammatory bowel diseases (IBDs) are recognized risk factors for this type of cancer. Despite a worldwide increase in the incidence of CRC, the risk of CRC-related death in IBD patients has declined over time, probably because of successful surveillance strategies, the use of more effective drugs in the management of remission and improved indications to colectomy. This notwithstanding, CRC 5-year survival in patients with IBD is poorer than in the general population. This review provides a summary of the epidemiological features, risk factors and various prevention strategies proposed for CRC in IBD patients. Moreover, there is a special focus on reporting and highlighting the various prevention strategies proposed by the most important international scientific societies, both in terms of chemoprevention and endoscopic surveillance. Indeed, in conducting the analysis, we have given attention to the current primary, secondary and tertiary prevention guidelines, attempting to emphasize unresolved research and clinical problems related to this topic in order to improve diagnostic strategies and management. MDPI 2022-08-31 /pmc/articles/PMC9454776/ /pubmed/36077786 http://dx.doi.org/10.3390/cancers14174254 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Marabotto, Elisa Kayali, Stefano Buccilli, Silvia Levo, Francesca Bodini, Giorgia Giannini, Edoardo G. Savarino, Vincenzo Savarino, Edoardo Vincenzo Colorectal Cancer in Inflammatory Bowel Diseases: Epidemiology and Prevention: A Review |
title | Colorectal Cancer in Inflammatory Bowel Diseases: Epidemiology and Prevention: A Review |
title_full | Colorectal Cancer in Inflammatory Bowel Diseases: Epidemiology and Prevention: A Review |
title_fullStr | Colorectal Cancer in Inflammatory Bowel Diseases: Epidemiology and Prevention: A Review |
title_full_unstemmed | Colorectal Cancer in Inflammatory Bowel Diseases: Epidemiology and Prevention: A Review |
title_short | Colorectal Cancer in Inflammatory Bowel Diseases: Epidemiology and Prevention: A Review |
title_sort | colorectal cancer in inflammatory bowel diseases: epidemiology and prevention: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454776/ https://www.ncbi.nlm.nih.gov/pubmed/36077786 http://dx.doi.org/10.3390/cancers14174254 |
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