Echocardiographic Features of the Ductus Arteriosus and the Foramen Ovale in a Hospital-Based Population of Neonatal Foals

SIMPLE SUMMARY: In fetal circulation, the distribution of oxygenated blood from the maternal placenta is facilitated by two intracardiac shunts. Oxygenated blood flows from the right atrium to the left heart through the foramen ovale, which is formed by the septum primum and septum secundum. Less oxygenated blood is directed to the placenta through the ductus arteriosus, which connects the pulmonary artery and the aorta. The ductus arteriosus and foramen ovale should close after birth. However, knowledge about the exact time of closure of those structures in foals is limited. The current study investigates the ultrasonographical closure of both the ductus arteriosus and the foramen ovale in healthy and diseased neonatal foals. Cardiac auscultation and ultrasound were performed on fifty foals. Cardiac murmurs were common, and in some foals, the ductus arteriosus was still open at ten days of age. The foramen ovale was not open; however, a fluttering motion of the septum primum into the left atrium was a common finding in healthy and diseased foals. The exact clinical importance of those findings needs to be further elucidated. ABSTRACT: The ductus arteriosus (DA) and foramen ovale (FO), including the septum primum (SP) and septum secundum (SS), are important structures in fetal circulation and are unexplored in neonatal equids. The objective of this study is to describe echocardiographic characteristics in a hospital-based population of neonatal foals. On days 2, 5 and 10 after parturition, cardiac ultrasound was performed, and clinical data were collected in healthy and diseased Warmblood foals. Fifty healthy (n = 15) and diseased (n = 35) Warmblood foals were examined. A left-sided and right-sided holosystolic murmur was audible in 98% (n = 42) and 51% (n = 22), respectively, on day 2; in 81% (n = 25) and 19% (n = 6) on day 5; and in 44% (n = 4) and 11% (n = 1) on day 10. The median grade of the systolic murmurs was higher when the DA was open. Flow through the DA could be visualized with color flow and continuous wave (CW) Doppler from the left parasternal long-axis view of the pulmonary artery in 40/43 foals on day 2, 9/31 foals on day 5 and 2/9 foals on day 10. The DA diameter was 2 ± 1 mm on day 2, 2 ± 1 mm on day 5 and 1 mm on day 10. The thickness of both septa of the FO was similar. The SP fluttered into the left atrium at all ages, but the maximal distance between the SP and SS decreased over time. In conclusion, cardiac murmurs, a patent DA and fluttering FO are frequent findings in neonatal foals. While these findings are probably physiological, the clinical importance needs to be further elucidated.