Cargando…

Inhibition of Aryl Hydrocarbon Receptor (AhR) Expression Disrupts Cell Proliferation and Alters Energy Metabolism and Fatty Acid Synthesis in Colon Cancer Cells

SIMPLE SUMMARY: Cancer cells undergo metabolic modifications in order to meet their high energetic demand. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor primarily known as a xenobiotic sensor. However, this receptor seems to have a wide range of physiological roles...

Descripción completa

Detalles Bibliográficos
Autores principales:	Karasová, Martina, Procházková, Jiřina, Tylichová, Zuzana, Fedr, Radek, Ciganek, Miroslav, Machala, Miroslav, Dvořák, Zdeněk, Vyhlídalová, Barbora, Zůvalová, Iveta, Ehrmann, Jiří, Bouchal, Jan, Andrysík, Zdeněk, Vondráček, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454859/ https://www.ncbi.nlm.nih.gov/pubmed/36077780 http://dx.doi.org/10.3390/cancers14174245

Ejemplares similares

Aryl Hydrocarbon Receptor (AhR) Limits the Inflammatory Responses in Human Lung Adenocarcinoma A549 Cells via Interference with NF-κB Signaling
por: Vázquez-Gómez, Gerardo, et al.
Publicado: (2022)

Complex Alterations of Fatty Acid Metabolism and Phospholipidome Uncovered in Isolated Colon Cancer Epithelial Cells
por: Hofmanová, Jiřina, et al.
Publicado: (2021)

Colon Cancer and Perturbations of the Sphingolipid Metabolism
por: Machala, Miroslav, et al.
Publicado: (2019)

Phospholipid profiling enables to discriminate tumor- and non-tumor-derived human colon epithelial cells: Phospholipidome similarities and differences in colon cancer cell lines and in patient-derived cell samples
por: Hofmanová, Jiřina, et al.
Publicado: (2020)

Gut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization
por: Vyhlídalová, Barbora, et al.
Publicado: (2020)

Jasmone Is a Ligand-Selective Allosteric Antagonist of Aryl Hydrocarbon Receptor (AhR)
por: Vrzal, Radim, et al.
Publicado: (2023)

Lung cancer associated with combustion particles and fine particulate matter (PM(2.5)) - The roles of polycyclic aromatic hydrocarbons (PAHs) and the aryl hydrocarbon receptor (AhR)
por: Holme, Jørn A., et al.
Publicado: (2023)

Antimigraine Drug Avitriptan Is a Ligand and Agonist of Human Aryl Hydrocarbon Receptor that Induces CYP1A1 in Hepatic and Intestinal Cells
por: Vyhlídalová, Barbora, et al.
Publicado: (2020)

Environmental Ligands of the Aryl Hydrocarbon Receptor and Their Effects in Models of Adult Liver Progenitor Cells
por: Vondráček, Jan, et al.
Publicado: (2016)

Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice
por: Ondrová, Karolína, et al.
Publicado: (2023)

Tumor-Suppressive Functions of the Aryl Hydrocarbon Receptor (AhR) and AhR as a Therapeutic Target in Cancer
por: Elson, Daniel J., et al.
Publicado: (2023)

The Landscape of AhR Regulators and Coregulators to Fine-Tune AhR Functions
por: Gargaro, Marco, et al.
Publicado: (2021)

Aryl Hydrocarbon Receptor (AhR)-Mediated Signaling in iPSC-Derived Human Motor Neurons
por: Imran, Saima Jalil, et al.
Publicado: (2022)

Changes in Sphingolipid Profile of Benzo[a]pyrene-Transformed Human Bronchial Epithelial Cells Are Reflected in the Altered Composition of Sphingolipids in Their Exosomes
por: Machala, Miroslav, et al.
Publicado: (2021)

High Skp2 expression is associated with a mesenchymal phenotype and increased tumorigenic potential of prostate cancer cells
por: Šimečková, Šárka, et al.
Publicado: (2019)

Ethyl Caffeate Can Inhibit Aryl Hydrocarbon Receptor (AhR) Signaling and AhR-Mediated Potentiation of Mast Cell Activation
por: Nguyen, Phuc-Tan, et al.
Publicado: (2023)

The Role of Aryl Hydrocarbon Receptor (AhR) in Brain Tumors
por: Perepechaeva, Maria L., et al.
Publicado: (2020)

The Role of Aryl-Hydrocarbon Receptor (AhR) in Osteoclast Differentiation and Function
por: Park, Robin, et al.
Publicado: (2020)

Serotonin Modulates AhR Activation by Interfering with CYP1A1-Mediated Clearance of AhR Ligands
por: Manzella, Christopher R., et al.
Publicado: (2020)

Coactivator Recruitment of AhR/ARNT1
por: Endler, Alexander, et al.
Publicado: (2014)

AhR signaling pathways and regulatory functions
por: Larigot, Lucie, et al.
Publicado: (2018)

Epigenetic Regulations of AhR in the Aspect of Immunomodulation
por: Wajda, Anna, et al.
Publicado: (2020)

AhR promotes phosphorylation of ARNT isoform 1 in human T cell malignancies as a switch for optimal AhR activity
por: Bourner, Luke A., et al.
Publicado: (2022)

Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?
por: Segner, Helmut, et al.
Publicado: (2021)

The Role of the Aryl Hydrocarbon Receptor (AhR) and Its Ligands in Breast Cancer
por: Safe, Stephen, et al.
Publicado: (2022)

Regulation of IDO2 by the Aryl Hydrocarbon Receptor (AhR) in Breast Cancer
por: Kado, Sarah Y., et al.
Publicado: (2023)

AhR and IDO1 in pathogenesis of Covid-19 and the “Systemic AhR Activation Syndrome:” a translational review and therapeutic perspectives
por: Turski, Waldemar A., et al.
Publicado: (2020)

Role of AhR/ARNT system in skin homeostasis
por: Furue, Masutaka, et al.
Publicado: (2014)

Bidirectional talk between AhR and Oct4
por: Kang, Bo, et al.
Publicado: (2015)

Induction of AhR-Mediated Gene Transcription by Coffee
por: Ishikawa, Toshio, et al.
Publicado: (2014)

New Treatments in Renal Cancer: The AhR Ligands
por: Itkin, Boris, et al.
Publicado: (2020)

Herbal Plants: The Role of AhR in Mediating Immunomodulation
por: Bungsu, Izzah, et al.
Publicado: (2021)

Screening of Cellular Stress Responses Induced by Ambient Aerosol Ultrafine Particle Fraction PM0.5 in A549 Cells
por: Šimečková, Pavlína, et al.
Publicado: (2019)

Global gene expression changes in human embryonic lung fibroblasts induced by organic extracts from respirable air particles
por: Líbalová, Helena, et al.
Publicado: (2012)

Benzimidazoisoquinolines: A New Class of Rapidly Metabolized Aryl Hydrocarbon Receptor (AhR) Ligands that Induce AhR-Dependent Tregs and Prevent Murine Graft-Versus-Host Disease
por: Punj, Sumit, et al.
Publicado: (2014)

The activation mechanism of the aryl hydrocarbon receptor (AhR) by molecular chaperone HSP90
por: Tsuji, Noriko, et al.
Publicado: (2014)

Endogenous regulation of the Akt pathway by the aryl hydrocarbon receptor (AhR) in lung fibroblasts
por: Shi, Fangyi, et al.
Publicado: (2021)

Role of the Arylhydrocarbon Receptor (AhR) in the Pathology of Asthma and COPD
por: Chiba, Takahito, et al.
Publicado: (2012)

Isopsoralen Enhanced Osteogenesis by Targeting AhR/ERα
por: Ge, Luna, et al.
Publicado: (2018)

AhR-deficiency as a cause of demyelinating disease and inflammation
por: Juricek, Ludmila, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_nqpj9buu7vqrm1vasmtj73fkt1