Cargando…

Apigetrin Promotes TNFα-Induced Apoptosis, Necroptosis, G2/M Phase Cell Cycle Arrest, and ROS Generation through Inhibition of NF-κB Pathway in Hep3B Liver Cancer Cells

Apigetrin (7-(β-D-glucopyranosyloxy)-4′,5-dihydroxyflavone), a glycoside bioactive dietary flavonoid derived from Taraxacum officinale and Teucrium gnaphalodes, is known to possess anticancer, antioxidant, and anti-inflammatory effects on numerous cancers. In the present study, we examined the effec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhosale, Pritam Bhagwan, Abusaliya, Abuyaseer, Kim, Hun Hwan, Ha, Sang Eun, Park, Min Yeong, Jeong, Se Hyo, Vetrivel, Preethi, Heo, Jeong Doo, Kim, Jin-A, Won, Chung kil, Kim, Hyun-Wook, Kim, Gon Sup
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454891/ https://www.ncbi.nlm.nih.gov/pubmed/36078142 http://dx.doi.org/10.3390/cells11172734

Ejemplares similares

Apigetrin Abrogates Lipopolysaccharide-Induced Inflammation in L6 Skeletal Muscle Cells through NF-κB/MAPK Signaling Pathways
por: Ha, Sang-Eun, et al.
Publicado: (2022)

Inhibition of Cell Proliferation and Cell Death by Apigetrin through Death Receptor-Mediated Pathway in Hepatocellular Cancer Cells
por: Bhosale, Pritam Bhagwan, et al.
Publicado: (2023)

Differences of Key Proteins between Apoptosis and Necroptosis
por: Park, Min Yeong, et al.
Publicado: (2021)

Prunetinoside Inhibits Lipopolysaccharide-Provoked Inflammatory Response via Suppressing NF-κB and Activating the JNK-Mediated Signaling Pathway in RAW264.7 Macrophage Cells
por: Abusaliya, Abuyaseer, et al.
Publicado: (2022)

Structural and Functional Properties of Activator Protein-1 in Cancer and Inflammation
por: Bhosale, Pritam Bhagwan, et al.
Publicado: (2022)

Investigation on the cellular mechanism of Prunetin evidenced through next generation sequencing and bioinformatic approaches against gastric cancer
por: Vetrivel, Preethi, et al.
Publicado: (2022)

Mechanistic Action of Cell Cycle Arrest and Intrinsic Apoptosis via Inhibiting Akt/mTOR and Activation of p38-MAPK Signaling Pathways in Hep3B Liver Cancer Cells by Prunetrin—A Flavonoid with Therapeutic Potential
por: Abusaliya, Abuyaseer, et al.
Publicado: (2023)

Scutellarein Inhibits LPS-Induced Inflammation through NF-κB/MAPKs Signaling Pathway in RAW264.7 Cells
por: Park, Min Yeong, et al.
Publicado: (2022)

Inhibition of Cell Proliferation and Metastasis by Scutellarein Regulating PI3K/Akt/NF-κB Signaling through PTEN Activation in Hepatocellular Carcinoma
por: Ha, Sang Eun, et al.
Publicado: (2021)

Cellular Regulation of Kynurenic Acid-Induced Cell Apoptosis Pathways in AGS Cells
por: Kim, Hun Hwan, et al.
Publicado: (2022)

Iridin Induces G2/M Phase Cell Cycle Arrest and Extrinsic Apoptotic Cell Death through PI3K/AKT Signaling Pathway in AGS Gastric Cancer Cells
por: Bhosale, Pritam-Bhagwan, et al.
Publicado: (2021)

A Network Pharmacological Approach to Reveal the Pharmacological Targets and Its Associated Biological Mechanisms of Prunetin-5-O-Glucoside against Gastric Cancer
por: Vetrivel, Preethi, et al.
Publicado: (2021)

Flavones: Six Selected Flavones and Their Related Signaling Pathways That Induce Apoptosis in Cancer
por: Jeong, Se Hyo, et al.
Publicado: (2022)

Identification of Kynurenic Acid-Induced Apoptotic Biomarkers in Gastric Cancer-Derived AGS Cells through Next-Generation Transcriptome Sequencing Analysis
por: Kim, Hun Hwan, et al.
Publicado: (2022)

Flavones: The Apoptosis in Prostate Cancer of Three Flavones Selected as Therapeutic Candidate Models
por: Jeong, Se Hyo, et al.
Publicado: (2023)

Potential Antioxidant and Anti-Inflammatory Effects of Lonicera japonica and Citri Reticulatae Pericarpium Polyphenolic Extract (LCPE)
por: Jeong, Se Hyo, et al.
Publicado: (2023)

Potential Joint Protective and Anti-Inflammatory Effects of Integrin α(v)β(3) in IL-1β-Treated Chondrocytes Cells
por: Kim, Hun Hwan, et al.
Publicado: (2023)

Cellular Function of Annexin A1 Protein Mimetic Peptide Ac2-26 in Human Skin Keratinocytes HaCaT and Fibroblast Detroit 551 Cells
por: Kim, Seong Min, et al.
Publicado: (2020)

Quantitative Proteomics Analysis for the Identification of Differential Protein Expression in Calf Muscles between Young and Old SD Rats Using Mass Spectrometry
por: Kim, Jin A., et al.
Publicado: (2021)

Scutellarein Induces Fas-Mediated Extrinsic Apoptosis and G2/M Cell Cycle Arrest in Hep3B Hepatocellular Carcinoma Cells
por: Ha, Sang Eun, et al.
Publicado: (2019)

Potential Antioxidant and Anti-Inflammatory Function of Gynura procumbens Polyphenols Ligand
por: Kim, Hun Hwan, et al.
Publicado: (2021)

Functions of polyphenols and its anticancer properties in biomedical research: a narrative review
por: Bhosale, Pritam Bhagwan, et al.
Publicado: (2020)

Function and Application of Flavonoids in the Breast Cancer
por: Park, Min Yeong, et al.
Publicado: (2022)

Compound Prunetin Induces Cell Death in Gastric Cancer Cell with Potent Anti-Proliferative Properties: In Vitro Assay, Molecular Docking, Dynamics, and ADMET Studies
por: Vetrivel, Preethi, et al.
Publicado: (2020)

Antioxidant effects of phenolic compounds in through the distillation of Lonicera japonica & Chenpi extract and anti-inflammation on skin keratinocyte
por: Kim, Hun Hwan, et al.
Publicado: (2023)

Comparative proteomic analysis uncovers potential biomarkers involved in the anticancer effect of Scutellarein in human gastric cancer cells
por: Saralamma, Venu Venkatarame Gowda, et al.
Publicado: (2020)

Sinensetin Induces Autophagic Cell Death through p53-Related AMPK/mTOR Signaling in Hepatocellular Carcinoma HepG2 Cells
por: Kim, Seong Min, et al.
Publicado: (2020)

Proteomic profiling of human HepG2 cells treated with hesperidin using antibody array
por: Yumnam, Silvia, et al.
Publicado: (2017)

Artemisia iwayomogi (Dowijigi) inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppressing the NF-κB signaling pathway
por: Kim, Seong Min, et al.
Publicado: (2020)

Comparative Proteomic Profiling of Tumor-Associated Proteins in Human Gastric Cancer Cells Treated with Pectolinarigenin
por: Lee, Ho Jeong, et al.
Publicado: (2018)

Proteome Profiling of Membrane-Free Stem Cell Components by Nano-LS/MS Analysis and Its Anti-Inflammatory Activity
por: Venkatarame Gowda Saralamma, Venu, et al.
Publicado: (2019)

Anthocyanins Derived from Vitis coignetiae Pulliat Contributes Anti-Cancer Effects by Suppressing NF-κB Pathways in Hep3B Human Hepatocellular Carcinoma Cells and In Vivo
por: Kim, Min Jeong, et al.
Publicado: (2020)

AKT, a Key Transmitter of HIF-1α and AR Signaling Pathways, Has a Critical Role in the Apigetrin-Mediated Anti-Cancer Effects in Prostate Cancer Cells
por: Lee, You-Kyung, et al.
Publicado: (2022)

ROS-Mediated Anti-Tumor Effect of Coptidis Rhizoma against Human Hepatocellular Carcinoma Hep3B Cells and Xenografts
por: Kim, So Young, et al.
Publicado: (2021)

Apigetrin inhibits adipogenesis in 3T3-L1 cells by downregulating PPARγ and CEBP-α
por: Hadrich, Fatma, et al.
Publicado: (2018)

Induction of Apoptosis by Coptisine in Hep3B Hepatocellular Carcinoma Cells through Activation of the ROS-Mediated JNK Signaling Pathway
por: Kim, So Young, et al.
Publicado: (2020)

Sinensetin regulates age-related sarcopenia in cultured primary thigh and calf muscle cells
por: Kim, Jin-A, et al.
Publicado: (2019)

Essential oil from Korean Chamaecyparis obtusa leaf ameliorates respiratory activity in Sprague-Dawley rats and exhibits protection from NF-κB-induced inflammation in WI38 fibroblast cells
por: Raha, Suchismita, et al.
Publicado: (2019)

Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulators
por: Seo, Jinho, et al.
Publicado: (2021)

Assessment of Anti-Inflammatory and Antioxidant Effects of Citrus unshiu Peel (CUP) Flavonoids on LPS-Stimulated RAW 264.7 Cells
por: Karthikeyan, Adhimoolam, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nfdhqje8mv0o74v37nk3r9m123