The Identification and Clinical Applications of Mutated Antigens in the Era of Immunotherapy

SIMPLE SUMMARY: In this review article, we highlight the process and importance of identifying neoantigens for immunotherapy for cancer. Although the process of identifying neoantigens may be time-consuming and costly, various efforts are being conducted at different stages of pre-clinical and clinical development to improve the process and identify neoantigens. This initiative will be imperative in developing the next generation of cost-efficient and potent immunotherapies against cancer. ABSTRACT: The era of personalized cancer therapy is here. Advances in the field of immunotherapy have paved the way for the development of individualized neoantigen-based therapies that can translate into favorable treatment outcomes and fewer side effects for patients. Addressing challenges related to the identification, access, and clinical application of neoantigens is critical to accelerating the development of individualized immunotherapy for cancer patients.