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Inhibition of Mcl-1 Synergistically Enhances the Antileukemic Activity of Gilteritinib and MRX-2843 in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia

FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (FLT3-ITD) mutations occur in about 25% of all acute myeloid leukemia (AML) patients and confer a poor prognosis. FLT3 inhibitors have been developed to treat patients with FLT3-mutated AML and have shown promise, though the acquisition o...

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Detalles Bibliográficos
Autores principales:	Wu, Shuangshuang, Edwards, Holly, Wang, Deying, Liu, Shuang, Qiao, Xinan, Carter, Jenna, Wang, Yue, Taub, Jeffrey W., Wang, Guan, Ge, Yubin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455003/ https://www.ncbi.nlm.nih.gov/pubmed/36078163 http://dx.doi.org/10.3390/cells11172752

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