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Potential Therapeutic Role of Mesenchymal-Derived Stem Cells as an Alternative Therapy to Combat COVID-19 through Cytokines Storm

Medical health systems continue to be challenged due to newly emerging COVID-19, and there is an urgent need for alternative approaches for treatment. An increasing number of clinical observations indicate cytokine storms to be associated with COVID-19 severity and also to be a significant cause of...

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Autores principales: Upadhyay, Tarun Kumar, Trivedi, Rashmi, Khan, Fahad, Pandey, Pratibha, Sharangi, Amit Baran, Goel, Harsh, Saeed, Mohd, Park, Moon Nyeo, Kim, Bonglee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455060/
https://www.ncbi.nlm.nih.gov/pubmed/36078094
http://dx.doi.org/10.3390/cells11172686
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author Upadhyay, Tarun Kumar
Trivedi, Rashmi
Khan, Fahad
Pandey, Pratibha
Sharangi, Amit Baran
Goel, Harsh
Saeed, Mohd
Park, Moon Nyeo
Kim, Bonglee
author_facet Upadhyay, Tarun Kumar
Trivedi, Rashmi
Khan, Fahad
Pandey, Pratibha
Sharangi, Amit Baran
Goel, Harsh
Saeed, Mohd
Park, Moon Nyeo
Kim, Bonglee
author_sort Upadhyay, Tarun Kumar
collection PubMed
description Medical health systems continue to be challenged due to newly emerging COVID-19, and there is an urgent need for alternative approaches for treatment. An increasing number of clinical observations indicate cytokine storms to be associated with COVID-19 severity and also to be a significant cause of death among COVID-19 patients. Cytokine storm involves the extensive proliferative and hyperactive activity of T and macrophage cells and the overproduction of pro-inflammatory cytokines. Stem cells are the type of cell having self-renewal properties and giving rise to differentiated cells. Currently, stem cell therapy is an exciting and promising therapeutic approach that can treat several diseases that were considered incurable in the past. It may be possible to develop novel methods to treat various diseases by identifying stem cells’ growth and differentiation factors. Treatment with mesenchymal stem cells (MSCs) in medicine is anticipated to be highly effective. The present review article is organized to put forward the positive arguments and implications in support of mesenchymal stem cell therapy as an alternative therapy to cytokine storms, to combat COVID-19. Using the immunomodulatory potential of the MSCs, it is possible to fight against COVID-19 and counterbalance the cytokine storm.
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spelling pubmed-94550602022-09-09 Potential Therapeutic Role of Mesenchymal-Derived Stem Cells as an Alternative Therapy to Combat COVID-19 through Cytokines Storm Upadhyay, Tarun Kumar Trivedi, Rashmi Khan, Fahad Pandey, Pratibha Sharangi, Amit Baran Goel, Harsh Saeed, Mohd Park, Moon Nyeo Kim, Bonglee Cells Review Medical health systems continue to be challenged due to newly emerging COVID-19, and there is an urgent need for alternative approaches for treatment. An increasing number of clinical observations indicate cytokine storms to be associated with COVID-19 severity and also to be a significant cause of death among COVID-19 patients. Cytokine storm involves the extensive proliferative and hyperactive activity of T and macrophage cells and the overproduction of pro-inflammatory cytokines. Stem cells are the type of cell having self-renewal properties and giving rise to differentiated cells. Currently, stem cell therapy is an exciting and promising therapeutic approach that can treat several diseases that were considered incurable in the past. It may be possible to develop novel methods to treat various diseases by identifying stem cells’ growth and differentiation factors. Treatment with mesenchymal stem cells (MSCs) in medicine is anticipated to be highly effective. The present review article is organized to put forward the positive arguments and implications in support of mesenchymal stem cell therapy as an alternative therapy to cytokine storms, to combat COVID-19. Using the immunomodulatory potential of the MSCs, it is possible to fight against COVID-19 and counterbalance the cytokine storm. MDPI 2022-08-29 /pmc/articles/PMC9455060/ /pubmed/36078094 http://dx.doi.org/10.3390/cells11172686 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Upadhyay, Tarun Kumar
Trivedi, Rashmi
Khan, Fahad
Pandey, Pratibha
Sharangi, Amit Baran
Goel, Harsh
Saeed, Mohd
Park, Moon Nyeo
Kim, Bonglee
Potential Therapeutic Role of Mesenchymal-Derived Stem Cells as an Alternative Therapy to Combat COVID-19 through Cytokines Storm
title Potential Therapeutic Role of Mesenchymal-Derived Stem Cells as an Alternative Therapy to Combat COVID-19 through Cytokines Storm
title_full Potential Therapeutic Role of Mesenchymal-Derived Stem Cells as an Alternative Therapy to Combat COVID-19 through Cytokines Storm
title_fullStr Potential Therapeutic Role of Mesenchymal-Derived Stem Cells as an Alternative Therapy to Combat COVID-19 through Cytokines Storm
title_full_unstemmed Potential Therapeutic Role of Mesenchymal-Derived Stem Cells as an Alternative Therapy to Combat COVID-19 through Cytokines Storm
title_short Potential Therapeutic Role of Mesenchymal-Derived Stem Cells as an Alternative Therapy to Combat COVID-19 through Cytokines Storm
title_sort potential therapeutic role of mesenchymal-derived stem cells as an alternative therapy to combat covid-19 through cytokines storm
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455060/
https://www.ncbi.nlm.nih.gov/pubmed/36078094
http://dx.doi.org/10.3390/cells11172686
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