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Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media
The application of immobilized sulfuric acid on silica gel (H(2)SO(4)-SiO(2)) as an efficient and easily reusable solid catalyst was explored in the synthesis of novel α-acyloxycarboxamide derivatives via a Passerini reaction of benzoic acid, aldehyde/ketone, and isocyanides. The Passerini adducts w...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455172/ https://www.ncbi.nlm.nih.gov/pubmed/36076923 http://dx.doi.org/10.3390/ijms23179529 |
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author | Salami, Sodeeq Aderotimi Manyeruke, Meloddy Siwe-Noundou, Xavier Krause, Rui Werner Maçedo |
author_facet | Salami, Sodeeq Aderotimi Manyeruke, Meloddy Siwe-Noundou, Xavier Krause, Rui Werner Maçedo |
author_sort | Salami, Sodeeq Aderotimi |
collection | PubMed |
description | The application of immobilized sulfuric acid on silica gel (H(2)SO(4)-SiO(2)) as an efficient and easily reusable solid catalyst was explored in the synthesis of novel α-acyloxycarboxamide derivatives via a Passerini reaction of benzoic acid, aldehyde/ketone, and isocyanides. The Passerini adducts were obtained in high to excellent yields within 10 min in aqueous media under catalytic conditions. The key advantages of the process include a short reaction time, high yields, the catalyst’s low cost, and the catalyst’s reusability. |
format | Online Article Text |
id | pubmed-9455172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94551722022-09-09 Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media Salami, Sodeeq Aderotimi Manyeruke, Meloddy Siwe-Noundou, Xavier Krause, Rui Werner Maçedo Int J Mol Sci Article The application of immobilized sulfuric acid on silica gel (H(2)SO(4)-SiO(2)) as an efficient and easily reusable solid catalyst was explored in the synthesis of novel α-acyloxycarboxamide derivatives via a Passerini reaction of benzoic acid, aldehyde/ketone, and isocyanides. The Passerini adducts were obtained in high to excellent yields within 10 min in aqueous media under catalytic conditions. The key advantages of the process include a short reaction time, high yields, the catalyst’s low cost, and the catalyst’s reusability. MDPI 2022-08-23 /pmc/articles/PMC9455172/ /pubmed/36076923 http://dx.doi.org/10.3390/ijms23179529 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Salami, Sodeeq Aderotimi Manyeruke, Meloddy Siwe-Noundou, Xavier Krause, Rui Werner Maçedo Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media |
title | Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media |
title_full | Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media |
title_fullStr | Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media |
title_full_unstemmed | Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media |
title_short | Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media |
title_sort | immobilized sulfuric acid on silica gel as highly efficient and heterogeneous catalyst for the one-pot synthesis of novel α-acyloxycarboxamides in aqueous media |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455172/ https://www.ncbi.nlm.nih.gov/pubmed/36076923 http://dx.doi.org/10.3390/ijms23179529 |
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