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Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media

The application of immobilized sulfuric acid on silica gel (H(2)SO(4)-SiO(2)) as an efficient and easily reusable solid catalyst was explored in the synthesis of novel α-acyloxycarboxamide derivatives via a Passerini reaction of benzoic acid, aldehyde/ketone, and isocyanides. The Passerini adducts w...

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Autores principales: Salami, Sodeeq Aderotimi, Manyeruke, Meloddy, Siwe-Noundou, Xavier, Krause, Rui Werner Maçedo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455172/
https://www.ncbi.nlm.nih.gov/pubmed/36076923
http://dx.doi.org/10.3390/ijms23179529
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author Salami, Sodeeq Aderotimi
Manyeruke, Meloddy
Siwe-Noundou, Xavier
Krause, Rui Werner Maçedo
author_facet Salami, Sodeeq Aderotimi
Manyeruke, Meloddy
Siwe-Noundou, Xavier
Krause, Rui Werner Maçedo
author_sort Salami, Sodeeq Aderotimi
collection PubMed
description The application of immobilized sulfuric acid on silica gel (H(2)SO(4)-SiO(2)) as an efficient and easily reusable solid catalyst was explored in the synthesis of novel α-acyloxycarboxamide derivatives via a Passerini reaction of benzoic acid, aldehyde/ketone, and isocyanides. The Passerini adducts were obtained in high to excellent yields within 10 min in aqueous media under catalytic conditions. The key advantages of the process include a short reaction time, high yields, the catalyst’s low cost, and the catalyst’s reusability.
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spelling pubmed-94551722022-09-09 Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media Salami, Sodeeq Aderotimi Manyeruke, Meloddy Siwe-Noundou, Xavier Krause, Rui Werner Maçedo Int J Mol Sci Article The application of immobilized sulfuric acid on silica gel (H(2)SO(4)-SiO(2)) as an efficient and easily reusable solid catalyst was explored in the synthesis of novel α-acyloxycarboxamide derivatives via a Passerini reaction of benzoic acid, aldehyde/ketone, and isocyanides. The Passerini adducts were obtained in high to excellent yields within 10 min in aqueous media under catalytic conditions. The key advantages of the process include a short reaction time, high yields, the catalyst’s low cost, and the catalyst’s reusability. MDPI 2022-08-23 /pmc/articles/PMC9455172/ /pubmed/36076923 http://dx.doi.org/10.3390/ijms23179529 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Salami, Sodeeq Aderotimi
Manyeruke, Meloddy
Siwe-Noundou, Xavier
Krause, Rui Werner Maçedo
Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media
title Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media
title_full Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media
title_fullStr Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media
title_full_unstemmed Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media
title_short Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media
title_sort immobilized sulfuric acid on silica gel as highly efficient and heterogeneous catalyst for the one-pot synthesis of novel α-acyloxycarboxamides in aqueous media
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455172/
https://www.ncbi.nlm.nih.gov/pubmed/36076923
http://dx.doi.org/10.3390/ijms23179529
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