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A rapid and sensitive UPLC-MS/MS method for simultaneous determination of four potential mutagenic impurities at trace levels in ripretinib drug substance

In the synthesis of ripretinib, a new oral tyrosine kinase inhibitor, impurities could arise directly from starting materials, reagents and intermediates. Among these process impurities, four specific intermediate impurities were found to contain the structural alerts of primary aromatic amine and a...

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Detalles Bibliográficos
Autores principales:	Huang, Yiwen, Xu, Qi, Lu, Hui, Li, Zhong, Wu, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455223/ https://www.ncbi.nlm.nih.gov/pubmed/36199346 http://dx.doi.org/10.1039/d2ra04505b

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