The Critical Role of AMPKα1 in Regulating Autophagy and Mitochondrial Respiration in IL-15-Stimulated mTORC1(Weak) Signal-Induced T Cell Memory: An Interplay between Yin (AMPKα1) and Yang (mTORC1) Energy Sensors in T Cell Differentiation

Two common γ-chain family cytokines IL-2 and IL-15 stimulate the same mammalian target of rapamycin complex-1 (mTORC1) signaling yet induce effector T (T(E)) and memory T (T(M)) cell differentiation via a poorly understood mechanism(s). Here, we prepared in vitro IL-2-stimulated T(E) (IL-2/T(E)) and...

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Detalles Bibliográficos
Autores principales: Ara, Anjuman, Wu, Zhaojia, Xu, Aizhang, Ahmed, Khawaja Ashfaque, Leary, Scot C., Islam, Md. Fahmid, Chibbar, Rajni, Wu, Yue, Xiang, Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455586/
https://www.ncbi.nlm.nih.gov/pubmed/36076931
http://dx.doi.org/10.3390/ijms23179534

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