Cargando…

Vps21 Directs the PI3K-PI(3)P-Atg21-Atg16 Module to Phagophores via Vps8 for Autophagy

Phosphatidylinositol 3-phosphate (PI(3)P) serves important functions in endocytosis, phagocytosis, and autophagy. PI(3)P is generated by Vps34 of the class III phosphatidylinositol 3-kinase (PI3K) complex. The Vps34-PI3K complex can be divided into Vps34-PI3K class II (containing Vps38, endosomal) a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Lei, You, Weiming, Sun, Dan, Xu, Hui, You, Xia, Xu, Haiqian, Wu, Zulin, Xie, Zhiping, Liang, Yongheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455592/ https://www.ncbi.nlm.nih.gov/pubmed/36076954 http://dx.doi.org/10.3390/ijms23179550

Ejemplares similares

A Vps21 endocytic module regulates autophagy
por: Chen, Yong, et al.
Publicado: (2014)

VPS37A directs ESCRT recruitment for phagophore closure
por: Takahashi, Yoshinori, et al.
Publicado: (2019)

VPS38/UVRAG and ATG14, the variant regulatory subunits of the ATG6/Beclin1-PI3K complexes, are crucial for the biogenesis of the yolk organelles and are transcriptionally regulated in the oocytes of the vector Rhodnius prolixus
por: Vieira, Priscila H., et al.
Publicado: (2021)

Atg9 establishes Atg2-dependent contact sites between the endoplasmic reticulum and phagophores
por: Gómez-Sánchez, Rubén, et al.
Publicado: (2018)

The dynamic Atg13-free conformation of the Atg1 EAT domain is required for phagophore expansion
por: Lin, Mary G., et al.
Publicado: (2018)

The dynamin Vps1 mediates Atg9 transport to the sites of autophagosome formation
por: Arlt, Henning, et al.
Publicado: (2023)

Ubiquitination of the PI3-kinase VPS-34 promotes VPS-34 stability and phagosome maturation
por: Liu, Jinchao, et al.
Publicado: (2018)

Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation
por: Ma, Benyu, et al.
Publicado: (2014)

Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy
por: Nazarko, Taras Y., et al.
Publicado: (2014)

Atg9 interactions via its transmembrane domains are required for phagophore expansion during autophagy
por: Chumpen Ramirez, Sabrina, et al.
Publicado: (2022)

Parallel phospholipid transfer by Vps13 and Atg2 determines autophagosome biogenesis dynamics
por: Dabrowski, Rahel, et al.
Publicado: (2023)

Coiled-coil-mediated dimerization of Atg16 is required for binding to the PROPPIN Atg21
por: Bueno-Arribas, Miranda, et al.
Publicado: (2023)

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila
por: Juhász, Gábor, et al.
Publicado: (2008)

Dual roles of Atg8−PE deconjugation by Atg4 in autophagy
por: Yu, Zhong-Qiu, et al.
Publicado: (2012)

Hypoxia Induces Autophagy in Human Dendritic Cells: Involvement of Class III PI3K/Vps34
por: Monaci, Sara, et al.
Publicado: (2022)

A conserved ATG2‐GABARAP family interaction is critical for phagophore formation
por: Bozic, Mihaela, et al.
Publicado: (2020)

Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex
por: Ohashi, Yohei, et al.
Publicado: (2016)

Corrigendum: Annexin A2 promotes phagophore assembly by enhancing Atg16(+) vesicle biogenesis and homotypic fusion
por: Morozova, Kateryna, et al.
Publicado: (2015)

Annexin A2 promotes phagophore assembly by enhancing Atg16L(+) vesicle biogenesis and homotypic fusion
por: Morozova, Kateryna, et al.
Publicado: (2015)

ATG9 raises the BAR for PI4P in autophagy
por: Shatz, Oren, et al.
Publicado: (2019)

Oxidation of Atg3 and Atg7 mediates inhibition of autophagy
por: Frudd, Karen, et al.
Publicado: (2018)

TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion
por: Tang, Zhenyuan, et al.
Publicado: (2019)

The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions
por: Xiong, Qiuhong, et al.
Publicado: (2015)

PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L‐associated PI3K activity
por: Xu, Da‐Qian, et al.
Publicado: (2016)

Uba1 functions in Atg7- and Atg3-independent autophagy
por: Chang, Tsun-Kai, et al.
Publicado: (2013)

NQO1 Deficiency Aggravates Renal Injury by Dysregulating Vps34/ATG14L Complex during Autophagy Initiation in Diabetic Nephropathy
por: Hong, Geum-Lan, et al.
Publicado: (2021)

Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7–Atg3 and Atg7–Atg10 structures
por: Kaiser, Stephen E., et al.
Publicado: (2012)

RAB33B recruits the ATG16L1 complex to the phagophore via a noncanonical RAB binding protein
por: Pantoom, Supansa, et al.
Publicado: (2020)

CMTM7 as a novel molecule of ATG14L-Beclin1-VPS34 complex enhances autophagy by Rab5 to regulate tumorigenicity
por: Liu, Baocai, et al.
Publicado: (2021)

Recruitment of Vps34 PI3K and enrichment of PI3P phosphoinositide in the viral replication compartment is crucial for replication of a positive-strand RNA virus
por: Feng, Zhike, et al.
Publicado: (2019)

Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L
por: Matsunaga, Kohichi, et al.
Publicado: (2010)

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma
por: Hwang, Seungmin, et al.
Publicado: (2012)

Effect of ATG12–ATG5-ATG16L1 autophagy E3-like complex on the ability of LC3/GABARAP proteins to induce vesicle tethering and fusion
por: Iriondo, Marina N., et al.
Publicado: (2023)

Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling
por: Segala, Gregory, et al.
Publicado: (2019)

PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress
por: Boukhalfa, Asma, et al.
Publicado: (2020)

Molecular Characterization and Functional Analysis of Three Autophagy Genes, BxATG5, BxATG9, and BxATG16, in Bursaphelenchus xylophilus
por: Liu, Hong-Bin, et al.
Publicado: (2019)

Partial inhibition of class III PI3K VPS-34 ameliorates motor aging and prolongs health span
por: Hu, Zhongliang, et al.
Publicado: (2023)

Closing the loop: Three musketeers of autophagy-ATG2, ATG18a, and ATG9
por: Mishra, Divya
Publicado: (2023)

Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes
por: Wartosch, Lena, et al.
Publicado: (2015)

A VPS15-like kinase regulates apicoplast biogenesis and autophagy by promoting PI3P generation in Toxoplasma gondii
por: Rawat, Rahul Singh, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_lr00t1giabhbru2croo47judsb