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Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases

The glucagon-like peptide-1 (GLP-1) is a pleiotropic hormone well known for its incretin effect in the glucose-dependent stimulation of insulin secretion. However, GLP-1 is also produced in the brain and displays a critical role in neuroprotection and inflammation by activating the GLP-1 receptor si...

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Autores principales: Diz-Chaves, Yolanda, Mastoor, Zainab, Spuch, Carlos, González-Matías, Lucas C., Mallo, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455625/
https://www.ncbi.nlm.nih.gov/pubmed/36076972
http://dx.doi.org/10.3390/ijms23179583
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author Diz-Chaves, Yolanda
Mastoor, Zainab
Spuch, Carlos
González-Matías, Lucas C.
Mallo, Federico
author_facet Diz-Chaves, Yolanda
Mastoor, Zainab
Spuch, Carlos
González-Matías, Lucas C.
Mallo, Federico
author_sort Diz-Chaves, Yolanda
collection PubMed
description The glucagon-like peptide-1 (GLP-1) is a pleiotropic hormone well known for its incretin effect in the glucose-dependent stimulation of insulin secretion. However, GLP-1 is also produced in the brain and displays a critical role in neuroprotection and inflammation by activating the GLP-1 receptor signaling pathways. Several studies in vivo and in vitro using preclinical models of neurodegenerative diseases show that GLP-1R activation has anti-inflammatory properties. This review explores the molecular mechanistic action of GLP-1 RAS in relation to inflammation in the brain. These findings update our knowledge of the potential benefits of GLP-1RAS actions in reducing the inflammatory response. These molecules emerge as a potential therapeutic tool in treating neurodegenerative diseases and neuroinflammatory pathologies.
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spelling pubmed-94556252022-09-09 Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases Diz-Chaves, Yolanda Mastoor, Zainab Spuch, Carlos González-Matías, Lucas C. Mallo, Federico Int J Mol Sci Review The glucagon-like peptide-1 (GLP-1) is a pleiotropic hormone well known for its incretin effect in the glucose-dependent stimulation of insulin secretion. However, GLP-1 is also produced in the brain and displays a critical role in neuroprotection and inflammation by activating the GLP-1 receptor signaling pathways. Several studies in vivo and in vitro using preclinical models of neurodegenerative diseases show that GLP-1R activation has anti-inflammatory properties. This review explores the molecular mechanistic action of GLP-1 RAS in relation to inflammation in the brain. These findings update our knowledge of the potential benefits of GLP-1RAS actions in reducing the inflammatory response. These molecules emerge as a potential therapeutic tool in treating neurodegenerative diseases and neuroinflammatory pathologies. MDPI 2022-08-24 /pmc/articles/PMC9455625/ /pubmed/36076972 http://dx.doi.org/10.3390/ijms23179583 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Diz-Chaves, Yolanda
Mastoor, Zainab
Spuch, Carlos
González-Matías, Lucas C.
Mallo, Federico
Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases
title Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases
title_full Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases
title_fullStr Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases
title_full_unstemmed Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases
title_short Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases
title_sort anti-inflammatory effects of glp-1 receptor activation in the brain in neurodegenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455625/
https://www.ncbi.nlm.nih.gov/pubmed/36076972
http://dx.doi.org/10.3390/ijms23179583
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