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Risk for lung-related diseases associated with welding fumes in an occupational population: Evidence from a Cox model

BACKGROUND: Welding fumes are a risk factor for welder pneumoconiosis. However, there is a lack of population information on the occurrence of welding fume-induced lung cancer, and little is known about the welding fume pathogenesis. METHODS: Welding fume and metal ion concentrations were assessed i...

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Autores principales: Li, Guangming, Jiang, Jinfeng, Liao, Yonggang, Wan, Siyu, Yao, Yong, Luo, Yongbin, Chen, Xuyu, Qian, Huiling, Dai, Xiayun, Yin, Wenjun, Min, Zhiteng, Yi, Guilin, Tan, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455702/
https://www.ncbi.nlm.nih.gov/pubmed/36091502
http://dx.doi.org/10.3389/fpubh.2022.990547
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author Li, Guangming
Jiang, Jinfeng
Liao, Yonggang
Wan, Siyu
Yao, Yong
Luo, Yongbin
Chen, Xuyu
Qian, Huiling
Dai, Xiayun
Yin, Wenjun
Min, Zhiteng
Yi, Guilin
Tan, Xiaodong
author_facet Li, Guangming
Jiang, Jinfeng
Liao, Yonggang
Wan, Siyu
Yao, Yong
Luo, Yongbin
Chen, Xuyu
Qian, Huiling
Dai, Xiayun
Yin, Wenjun
Min, Zhiteng
Yi, Guilin
Tan, Xiaodong
author_sort Li, Guangming
collection PubMed
description BACKGROUND: Welding fumes are a risk factor for welder pneumoconiosis. However, there is a lack of population information on the occurrence of welding fume-induced lung cancer, and little is known about the welding fume pathogenesis. METHODS: Welding fume and metal ion concentrations were assessed in a vehicle factory in Wuhan. A Cox regression model estimated lung-related disease risk in workers by independent and combined factors. RESULTS: Workers' exposures were divided into four grades; the highest exposure was among the welders in the maintenance workshop, the highest Mn and Fe exposure was 4 grades, and the highest Cr exposure was 3 grades. Subgroup analysis found that the risk of lung-related disease was 2.17 (95% CI: 1.31–3.57, p < 0.05) in welders compared with non-welders, and the risk of pulmonary disease in male welders was 2.24 (95% CI: 1.34–3.73, p < 0.05) compared to non-welders. Smoking welders had a 2.44 (95% CI: 1.32–4.51, p < 0.01) higher incidence of lung-related diseases than non-welders. Total years of work as an independent protective factor for lung-related disease risk was 0.72 (95% CI: 0.66–0.78, p < 0.01). As an independent risk factor, high-high and high-low exposure had a 5.39 (95% CI: 2.52–11.52, p < 0.001) and 2.17 (95% CI: 1.07–4.41, p < 0.05) higher risk for lung-related diseases, respectively. CONCLUSIONS: High welding fume exposure is a significant risk factor for lung-related disease in workers.
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spelling pubmed-94557022022-09-09 Risk for lung-related diseases associated with welding fumes in an occupational population: Evidence from a Cox model Li, Guangming Jiang, Jinfeng Liao, Yonggang Wan, Siyu Yao, Yong Luo, Yongbin Chen, Xuyu Qian, Huiling Dai, Xiayun Yin, Wenjun Min, Zhiteng Yi, Guilin Tan, Xiaodong Front Public Health Public Health BACKGROUND: Welding fumes are a risk factor for welder pneumoconiosis. However, there is a lack of population information on the occurrence of welding fume-induced lung cancer, and little is known about the welding fume pathogenesis. METHODS: Welding fume and metal ion concentrations were assessed in a vehicle factory in Wuhan. A Cox regression model estimated lung-related disease risk in workers by independent and combined factors. RESULTS: Workers' exposures were divided into four grades; the highest exposure was among the welders in the maintenance workshop, the highest Mn and Fe exposure was 4 grades, and the highest Cr exposure was 3 grades. Subgroup analysis found that the risk of lung-related disease was 2.17 (95% CI: 1.31–3.57, p < 0.05) in welders compared with non-welders, and the risk of pulmonary disease in male welders was 2.24 (95% CI: 1.34–3.73, p < 0.05) compared to non-welders. Smoking welders had a 2.44 (95% CI: 1.32–4.51, p < 0.01) higher incidence of lung-related diseases than non-welders. Total years of work as an independent protective factor for lung-related disease risk was 0.72 (95% CI: 0.66–0.78, p < 0.01). As an independent risk factor, high-high and high-low exposure had a 5.39 (95% CI: 2.52–11.52, p < 0.001) and 2.17 (95% CI: 1.07–4.41, p < 0.05) higher risk for lung-related diseases, respectively. CONCLUSIONS: High welding fume exposure is a significant risk factor for lung-related disease in workers. Frontiers Media S.A. 2022-08-25 /pmc/articles/PMC9455702/ /pubmed/36091502 http://dx.doi.org/10.3389/fpubh.2022.990547 Text en Copyright © 2022 Li, Jiang, Liao, Wan, Yao, Luo, Chen, Qian, Dai, Yin, Min, Yi and Tan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Li, Guangming
Jiang, Jinfeng
Liao, Yonggang
Wan, Siyu
Yao, Yong
Luo, Yongbin
Chen, Xuyu
Qian, Huiling
Dai, Xiayun
Yin, Wenjun
Min, Zhiteng
Yi, Guilin
Tan, Xiaodong
Risk for lung-related diseases associated with welding fumes in an occupational population: Evidence from a Cox model
title Risk for lung-related diseases associated with welding fumes in an occupational population: Evidence from a Cox model
title_full Risk for lung-related diseases associated with welding fumes in an occupational population: Evidence from a Cox model
title_fullStr Risk for lung-related diseases associated with welding fumes in an occupational population: Evidence from a Cox model
title_full_unstemmed Risk for lung-related diseases associated with welding fumes in an occupational population: Evidence from a Cox model
title_short Risk for lung-related diseases associated with welding fumes in an occupational population: Evidence from a Cox model
title_sort risk for lung-related diseases associated with welding fumes in an occupational population: evidence from a cox model
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455702/
https://www.ncbi.nlm.nih.gov/pubmed/36091502
http://dx.doi.org/10.3389/fpubh.2022.990547
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