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Food and Gut Microbiota-Derived Metabolites in Nonalcoholic Fatty Liver Disease
Diet and lifestyle are crucial factors that influence the susceptibility of humans to nonalcoholic fatty liver disease (NAFLD). Personalized diet patterns chronically affect the composition and activity of microbiota in the human gut; consequently, nutrition-related dysbiosis exacerbates NAFLD via t...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455821/ https://www.ncbi.nlm.nih.gov/pubmed/36076888 http://dx.doi.org/10.3390/foods11172703 |
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author | Jeong, Min Kyo Min, Byeong Hyun Choi, Ye Rin Hyun, Ji Ye Park, Hee Jin Eom, Jung A Won, Sung Min Jeong, Jin Ju Oh, Ki Kwang Gupta, Haripriya Ganesan, Raja Sharma, Satya Priya Yoon, Sang Jun Choi, Mi Ran Kim, Dong Joon Suk, Ki Tae |
author_facet | Jeong, Min Kyo Min, Byeong Hyun Choi, Ye Rin Hyun, Ji Ye Park, Hee Jin Eom, Jung A Won, Sung Min Jeong, Jin Ju Oh, Ki Kwang Gupta, Haripriya Ganesan, Raja Sharma, Satya Priya Yoon, Sang Jun Choi, Mi Ran Kim, Dong Joon Suk, Ki Tae |
author_sort | Jeong, Min Kyo |
collection | PubMed |
description | Diet and lifestyle are crucial factors that influence the susceptibility of humans to nonalcoholic fatty liver disease (NAFLD). Personalized diet patterns chronically affect the composition and activity of microbiota in the human gut; consequently, nutrition-related dysbiosis exacerbates NAFLD via the gut–liver axis. Recent advances in diagnostic technology for gut microbes and microbiota-derived metabolites have led to advances in the diagnosis, treatment, and prognosis of NAFLD. Microbiota-derived metabolites, including tryptophan, short-chain fatty acid, fat, fructose, or bile acid, regulate the pathophysiology of NAFLD. The microbiota metabolize nutrients, and metabolites are closely related to the development of NAFLD. In this review, we discuss the influence of nutrients, gut microbes, their corresponding metabolites, and metabolism in the pathogenesis of NAFLD. |
format | Online Article Text |
id | pubmed-9455821 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94558212022-09-09 Food and Gut Microbiota-Derived Metabolites in Nonalcoholic Fatty Liver Disease Jeong, Min Kyo Min, Byeong Hyun Choi, Ye Rin Hyun, Ji Ye Park, Hee Jin Eom, Jung A Won, Sung Min Jeong, Jin Ju Oh, Ki Kwang Gupta, Haripriya Ganesan, Raja Sharma, Satya Priya Yoon, Sang Jun Choi, Mi Ran Kim, Dong Joon Suk, Ki Tae Foods Review Diet and lifestyle are crucial factors that influence the susceptibility of humans to nonalcoholic fatty liver disease (NAFLD). Personalized diet patterns chronically affect the composition and activity of microbiota in the human gut; consequently, nutrition-related dysbiosis exacerbates NAFLD via the gut–liver axis. Recent advances in diagnostic technology for gut microbes and microbiota-derived metabolites have led to advances in the diagnosis, treatment, and prognosis of NAFLD. Microbiota-derived metabolites, including tryptophan, short-chain fatty acid, fat, fructose, or bile acid, regulate the pathophysiology of NAFLD. The microbiota metabolize nutrients, and metabolites are closely related to the development of NAFLD. In this review, we discuss the influence of nutrients, gut microbes, their corresponding metabolites, and metabolism in the pathogenesis of NAFLD. MDPI 2022-09-05 /pmc/articles/PMC9455821/ /pubmed/36076888 http://dx.doi.org/10.3390/foods11172703 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jeong, Min Kyo Min, Byeong Hyun Choi, Ye Rin Hyun, Ji Ye Park, Hee Jin Eom, Jung A Won, Sung Min Jeong, Jin Ju Oh, Ki Kwang Gupta, Haripriya Ganesan, Raja Sharma, Satya Priya Yoon, Sang Jun Choi, Mi Ran Kim, Dong Joon Suk, Ki Tae Food and Gut Microbiota-Derived Metabolites in Nonalcoholic Fatty Liver Disease |
title | Food and Gut Microbiota-Derived Metabolites in Nonalcoholic Fatty Liver Disease |
title_full | Food and Gut Microbiota-Derived Metabolites in Nonalcoholic Fatty Liver Disease |
title_fullStr | Food and Gut Microbiota-Derived Metabolites in Nonalcoholic Fatty Liver Disease |
title_full_unstemmed | Food and Gut Microbiota-Derived Metabolites in Nonalcoholic Fatty Liver Disease |
title_short | Food and Gut Microbiota-Derived Metabolites in Nonalcoholic Fatty Liver Disease |
title_sort | food and gut microbiota-derived metabolites in nonalcoholic fatty liver disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455821/ https://www.ncbi.nlm.nih.gov/pubmed/36076888 http://dx.doi.org/10.3390/foods11172703 |
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