Mutant WDR45 Leads to Altered Ferritinophagy and Ferroptosis in β-Propeller Protein-Associated Neurodegeneration

Beta-propeller protein-associated neurodegeneration (BPAN) is a subtype of neurodegeneration with brain iron accumulation (NBIA) caused by loss-of-function variants in WDR45. The underlying mechanism of iron accumulation in WDR45 deficiency remains elusive. We established a primary skin fibroblast c...

Descripción completa

Detalles Bibliográficos
Autores principales: Diaw, Sokhna Haissatou, Ganos, Christos, Zittel, Simone, Plötze-Martin, Kirstin, Kulikovskaja, Leonora, Vos, Melissa, Westenberger, Ana, Rakovic, Aleksandar, Lohmann, Katja, Dulovic-Mahlow, Marija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455908/
https://www.ncbi.nlm.nih.gov/pubmed/36076926
http://dx.doi.org/10.3390/ijms23179524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455908/
https://www.ncbi.nlm.nih.gov/pubmed/36076926
http://dx.doi.org/10.3390/ijms23179524

Ejemplares similares