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Immunoglobulin Superfamily Containing Leucine-Rich Repeat (Islr) Participates in IL-6-Mediated Crosstalk between Muscle and Brown Adipose Tissue to Regulate Energy Homeostasis

Brown adipose tissue (BAT) is functionally linked to skeletal muscle because both tissues originate from a common progenitor cell, but the precise mechanism controlling muscle-to-brown-fat communication is insufficiently understood. This report demonstrates that the immunoglobulin superfamily contai...

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Autores principales: Liu, Chang, Liu, Jin, Wang, Tongtong, Su, Yang, Li, Lei, Lan, Miaomiao, Yu, Yingying, Liu, Fan, Xiong, Lei, Wang, Kun, Chen, Meijing, Li, Na, Xu, Qing, Hu, Yue, Jia, Yuxin, Meng, Qingyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455994/
https://www.ncbi.nlm.nih.gov/pubmed/36077405
http://dx.doi.org/10.3390/ijms231710008
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author Liu, Chang
Liu, Jin
Wang, Tongtong
Su, Yang
Li, Lei
Lan, Miaomiao
Yu, Yingying
Liu, Fan
Xiong, Lei
Wang, Kun
Chen, Meijing
Li, Na
Xu, Qing
Hu, Yue
Jia, Yuxin
Meng, Qingyong
author_facet Liu, Chang
Liu, Jin
Wang, Tongtong
Su, Yang
Li, Lei
Lan, Miaomiao
Yu, Yingying
Liu, Fan
Xiong, Lei
Wang, Kun
Chen, Meijing
Li, Na
Xu, Qing
Hu, Yue
Jia, Yuxin
Meng, Qingyong
author_sort Liu, Chang
collection PubMed
description Brown adipose tissue (BAT) is functionally linked to skeletal muscle because both tissues originate from a common progenitor cell, but the precise mechanism controlling muscle-to-brown-fat communication is insufficiently understood. This report demonstrates that the immunoglobulin superfamily containing leucine-rich repeat (Islr), a marker of mesenchymal stromal/stem cells, is critical for the control of BAT mitochondrial function and whole-body energy homeostasis. The mice loss of Islr in BAT after cardiotoxin injury resulted in improved mitochondrial function, increased energy expenditure, and enhanced thermogenesis. Importantly, it was found that interleukin-6 (IL-6), as a myokine, participates in this process. Mechanistically, Islr interacts with NADH: Ubiquinone Oxidoreductase Core Subunit S2 (Ndufs2) to regulate IL-6 signaling; consequently, Islr functions as a brake that prevents IL-6 from promoting BAT activity. Together, these findings reveal a previously unrecognized mechanism for muscle-BAT cross talk driven by Islr, Ndufs2, and IL-6 to regulate energy homeostasis, which may be used as a potential therapeutic target in obesity.
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spelling pubmed-94559942022-09-09 Immunoglobulin Superfamily Containing Leucine-Rich Repeat (Islr) Participates in IL-6-Mediated Crosstalk between Muscle and Brown Adipose Tissue to Regulate Energy Homeostasis Liu, Chang Liu, Jin Wang, Tongtong Su, Yang Li, Lei Lan, Miaomiao Yu, Yingying Liu, Fan Xiong, Lei Wang, Kun Chen, Meijing Li, Na Xu, Qing Hu, Yue Jia, Yuxin Meng, Qingyong Int J Mol Sci Article Brown adipose tissue (BAT) is functionally linked to skeletal muscle because both tissues originate from a common progenitor cell, but the precise mechanism controlling muscle-to-brown-fat communication is insufficiently understood. This report demonstrates that the immunoglobulin superfamily containing leucine-rich repeat (Islr), a marker of mesenchymal stromal/stem cells, is critical for the control of BAT mitochondrial function and whole-body energy homeostasis. The mice loss of Islr in BAT after cardiotoxin injury resulted in improved mitochondrial function, increased energy expenditure, and enhanced thermogenesis. Importantly, it was found that interleukin-6 (IL-6), as a myokine, participates in this process. Mechanistically, Islr interacts with NADH: Ubiquinone Oxidoreductase Core Subunit S2 (Ndufs2) to regulate IL-6 signaling; consequently, Islr functions as a brake that prevents IL-6 from promoting BAT activity. Together, these findings reveal a previously unrecognized mechanism for muscle-BAT cross talk driven by Islr, Ndufs2, and IL-6 to regulate energy homeostasis, which may be used as a potential therapeutic target in obesity. MDPI 2022-09-02 /pmc/articles/PMC9455994/ /pubmed/36077405 http://dx.doi.org/10.3390/ijms231710008 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Chang
Liu, Jin
Wang, Tongtong
Su, Yang
Li, Lei
Lan, Miaomiao
Yu, Yingying
Liu, Fan
Xiong, Lei
Wang, Kun
Chen, Meijing
Li, Na
Xu, Qing
Hu, Yue
Jia, Yuxin
Meng, Qingyong
Immunoglobulin Superfamily Containing Leucine-Rich Repeat (Islr) Participates in IL-6-Mediated Crosstalk between Muscle and Brown Adipose Tissue to Regulate Energy Homeostasis
title Immunoglobulin Superfamily Containing Leucine-Rich Repeat (Islr) Participates in IL-6-Mediated Crosstalk between Muscle and Brown Adipose Tissue to Regulate Energy Homeostasis
title_full Immunoglobulin Superfamily Containing Leucine-Rich Repeat (Islr) Participates in IL-6-Mediated Crosstalk between Muscle and Brown Adipose Tissue to Regulate Energy Homeostasis
title_fullStr Immunoglobulin Superfamily Containing Leucine-Rich Repeat (Islr) Participates in IL-6-Mediated Crosstalk between Muscle and Brown Adipose Tissue to Regulate Energy Homeostasis
title_full_unstemmed Immunoglobulin Superfamily Containing Leucine-Rich Repeat (Islr) Participates in IL-6-Mediated Crosstalk between Muscle and Brown Adipose Tissue to Regulate Energy Homeostasis
title_short Immunoglobulin Superfamily Containing Leucine-Rich Repeat (Islr) Participates in IL-6-Mediated Crosstalk between Muscle and Brown Adipose Tissue to Regulate Energy Homeostasis
title_sort immunoglobulin superfamily containing leucine-rich repeat (islr) participates in il-6-mediated crosstalk between muscle and brown adipose tissue to regulate energy homeostasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455994/
https://www.ncbi.nlm.nih.gov/pubmed/36077405
http://dx.doi.org/10.3390/ijms231710008
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