Monoclonal Antibody Engineering and Design to Modulate FcRn Activities: A Comprehensive Review

Understanding the biological mechanisms underlying the pH-dependent nature of FcRn binding, as well as the various factors influencing the affinity to FcRn, was concurrent with the arrival of the first recombinant IgG monoclonal antibodies (mAbs) and IgG Fc-fusion proteins in clinical practice. IgG...

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Detalles Bibliográficos
Autores principales: Ramdani, Yanis, Lamamy, Juliette, Watier, Hervé, Gouilleux-Gruart, Valérie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455995/
https://www.ncbi.nlm.nih.gov/pubmed/36077002
http://dx.doi.org/10.3390/ijms23179604

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455995/
https://www.ncbi.nlm.nih.gov/pubmed/36077002
http://dx.doi.org/10.3390/ijms23179604

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