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Salivary Redox Homeostasis in Human Health and Disease
Homeostasis is a self-regulatory dynamic process that maintains a stable internal environment in the human body. These regulations are essential for the optimal functioning of enzymes necessary for human health. Homeostasis elucidates disrupted mechanisms leading to the development of various pathol...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455999/ https://www.ncbi.nlm.nih.gov/pubmed/36077473 http://dx.doi.org/10.3390/ijms231710076 |
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author | Čižmárová, Beáta Tomečková, Vladimíra Hubková, Beáta Hurajtová, Anna Ohlasová, Jana Birková, Anna |
author_facet | Čižmárová, Beáta Tomečková, Vladimíra Hubková, Beáta Hurajtová, Anna Ohlasová, Jana Birková, Anna |
author_sort | Čižmárová, Beáta |
collection | PubMed |
description | Homeostasis is a self-regulatory dynamic process that maintains a stable internal environment in the human body. These regulations are essential for the optimal functioning of enzymes necessary for human health. Homeostasis elucidates disrupted mechanisms leading to the development of various pathological conditions caused by oxidative stress. In our work, we discuss redox homeostasis and salivary antioxidant activity during healthy periods and in periods of disease: dental carries, oral cavity cancer, periodontal diseases, cardiovascular diseases, diabetes mellitus, systemic sclerosis, and pancreatitis. The composition of saliva reflects dynamic changes in the organism, which makes it an excellent tool for determining clinically valuable biomarkers. The oral cavity and saliva may form the first line of defense against oxidative stress. Analysis of salivary antioxidants may be helpful as a diagnostic, prognostic, and therapeutic marker of not only oral, but also systemic health. |
format | Online Article Text |
id | pubmed-9455999 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94559992022-09-09 Salivary Redox Homeostasis in Human Health and Disease Čižmárová, Beáta Tomečková, Vladimíra Hubková, Beáta Hurajtová, Anna Ohlasová, Jana Birková, Anna Int J Mol Sci Review Homeostasis is a self-regulatory dynamic process that maintains a stable internal environment in the human body. These regulations are essential for the optimal functioning of enzymes necessary for human health. Homeostasis elucidates disrupted mechanisms leading to the development of various pathological conditions caused by oxidative stress. In our work, we discuss redox homeostasis and salivary antioxidant activity during healthy periods and in periods of disease: dental carries, oral cavity cancer, periodontal diseases, cardiovascular diseases, diabetes mellitus, systemic sclerosis, and pancreatitis. The composition of saliva reflects dynamic changes in the organism, which makes it an excellent tool for determining clinically valuable biomarkers. The oral cavity and saliva may form the first line of defense against oxidative stress. Analysis of salivary antioxidants may be helpful as a diagnostic, prognostic, and therapeutic marker of not only oral, but also systemic health. MDPI 2022-09-03 /pmc/articles/PMC9455999/ /pubmed/36077473 http://dx.doi.org/10.3390/ijms231710076 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Čižmárová, Beáta Tomečková, Vladimíra Hubková, Beáta Hurajtová, Anna Ohlasová, Jana Birková, Anna Salivary Redox Homeostasis in Human Health and Disease |
title | Salivary Redox Homeostasis in Human Health and Disease |
title_full | Salivary Redox Homeostasis in Human Health and Disease |
title_fullStr | Salivary Redox Homeostasis in Human Health and Disease |
title_full_unstemmed | Salivary Redox Homeostasis in Human Health and Disease |
title_short | Salivary Redox Homeostasis in Human Health and Disease |
title_sort | salivary redox homeostasis in human health and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455999/ https://www.ncbi.nlm.nih.gov/pubmed/36077473 http://dx.doi.org/10.3390/ijms231710076 |
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