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Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study
The natural sweeteners erythritol and xylitol might be helpful to reduce sugar consumption and therefore prevent obesity and diabetes. The aim of the present study was to determine the absorption and metabolization into erythronate of different concentrations of erythritol and xylitol. Seventeen hea...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456049/ https://www.ncbi.nlm.nih.gov/pubmed/36077269 http://dx.doi.org/10.3390/ijms23179867 |
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author | Bordier, Valentine Teysseire, Fabienne Senner, Frank Schlotterbeck, Götz Drewe, Jürgen Beglinger, Christoph Wölnerhanssen, Bettina K. Meyer-Gerspach, Anne Christin |
author_facet | Bordier, Valentine Teysseire, Fabienne Senner, Frank Schlotterbeck, Götz Drewe, Jürgen Beglinger, Christoph Wölnerhanssen, Bettina K. Meyer-Gerspach, Anne Christin |
author_sort | Bordier, Valentine |
collection | PubMed |
description | The natural sweeteners erythritol and xylitol might be helpful to reduce sugar consumption and therefore prevent obesity and diabetes. The aim of the present study was to determine the absorption and metabolization into erythronate of different concentrations of erythritol and xylitol. Seventeen healthy lean participants received intragastric solutions of 10, 25, or 50 g erythritol or 7, 17, or 35 g xylitol on three study days in a randomized order. The study was double blinded with respect to the doses administered. We assessed plasma concentrations of erythritol, xylitol, and erythronate at fixed time intervals after administration with gas chromatography-mass spectrometry. We found: (i) a dose-dependent and saturable absorption of erythritol, (ii) a very low absorption of xylitol, (iii) a dose-dependent metabolization of erythritol into erythronate, and (iv) no metabolization of xylitol into erythronate. The implications of the metabolization of erythritol into erythronate for human health remain to be determined and more research in this area is needed. |
format | Online Article Text |
id | pubmed-9456049 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94560492022-09-09 Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study Bordier, Valentine Teysseire, Fabienne Senner, Frank Schlotterbeck, Götz Drewe, Jürgen Beglinger, Christoph Wölnerhanssen, Bettina K. Meyer-Gerspach, Anne Christin Int J Mol Sci Article The natural sweeteners erythritol and xylitol might be helpful to reduce sugar consumption and therefore prevent obesity and diabetes. The aim of the present study was to determine the absorption and metabolization into erythronate of different concentrations of erythritol and xylitol. Seventeen healthy lean participants received intragastric solutions of 10, 25, or 50 g erythritol or 7, 17, or 35 g xylitol on three study days in a randomized order. The study was double blinded with respect to the doses administered. We assessed plasma concentrations of erythritol, xylitol, and erythronate at fixed time intervals after administration with gas chromatography-mass spectrometry. We found: (i) a dose-dependent and saturable absorption of erythritol, (ii) a very low absorption of xylitol, (iii) a dose-dependent metabolization of erythritol into erythronate, and (iv) no metabolization of xylitol into erythronate. The implications of the metabolization of erythritol into erythronate for human health remain to be determined and more research in this area is needed. MDPI 2022-08-30 /pmc/articles/PMC9456049/ /pubmed/36077269 http://dx.doi.org/10.3390/ijms23179867 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bordier, Valentine Teysseire, Fabienne Senner, Frank Schlotterbeck, Götz Drewe, Jürgen Beglinger, Christoph Wölnerhanssen, Bettina K. Meyer-Gerspach, Anne Christin Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study |
title | Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study |
title_full | Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study |
title_fullStr | Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study |
title_full_unstemmed | Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study |
title_short | Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study |
title_sort | absorption and metabolism of the natural sweeteners erythritol and xylitol in humans: a dose-ranging study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456049/ https://www.ncbi.nlm.nih.gov/pubmed/36077269 http://dx.doi.org/10.3390/ijms23179867 |
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