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Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study

The natural sweeteners erythritol and xylitol might be helpful to reduce sugar consumption and therefore prevent obesity and diabetes. The aim of the present study was to determine the absorption and metabolization into erythronate of different concentrations of erythritol and xylitol. Seventeen hea...

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Autores principales: Bordier, Valentine, Teysseire, Fabienne, Senner, Frank, Schlotterbeck, Götz, Drewe, Jürgen, Beglinger, Christoph, Wölnerhanssen, Bettina K., Meyer-Gerspach, Anne Christin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456049/
https://www.ncbi.nlm.nih.gov/pubmed/36077269
http://dx.doi.org/10.3390/ijms23179867
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author Bordier, Valentine
Teysseire, Fabienne
Senner, Frank
Schlotterbeck, Götz
Drewe, Jürgen
Beglinger, Christoph
Wölnerhanssen, Bettina K.
Meyer-Gerspach, Anne Christin
author_facet Bordier, Valentine
Teysseire, Fabienne
Senner, Frank
Schlotterbeck, Götz
Drewe, Jürgen
Beglinger, Christoph
Wölnerhanssen, Bettina K.
Meyer-Gerspach, Anne Christin
author_sort Bordier, Valentine
collection PubMed
description The natural sweeteners erythritol and xylitol might be helpful to reduce sugar consumption and therefore prevent obesity and diabetes. The aim of the present study was to determine the absorption and metabolization into erythronate of different concentrations of erythritol and xylitol. Seventeen healthy lean participants received intragastric solutions of 10, 25, or 50 g erythritol or 7, 17, or 35 g xylitol on three study days in a randomized order. The study was double blinded with respect to the doses administered. We assessed plasma concentrations of erythritol, xylitol, and erythronate at fixed time intervals after administration with gas chromatography-mass spectrometry. We found: (i) a dose-dependent and saturable absorption of erythritol, (ii) a very low absorption of xylitol, (iii) a dose-dependent metabolization of erythritol into erythronate, and (iv) no metabolization of xylitol into erythronate. The implications of the metabolization of erythritol into erythronate for human health remain to be determined and more research in this area is needed.
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spelling pubmed-94560492022-09-09 Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study Bordier, Valentine Teysseire, Fabienne Senner, Frank Schlotterbeck, Götz Drewe, Jürgen Beglinger, Christoph Wölnerhanssen, Bettina K. Meyer-Gerspach, Anne Christin Int J Mol Sci Article The natural sweeteners erythritol and xylitol might be helpful to reduce sugar consumption and therefore prevent obesity and diabetes. The aim of the present study was to determine the absorption and metabolization into erythronate of different concentrations of erythritol and xylitol. Seventeen healthy lean participants received intragastric solutions of 10, 25, or 50 g erythritol or 7, 17, or 35 g xylitol on three study days in a randomized order. The study was double blinded with respect to the doses administered. We assessed plasma concentrations of erythritol, xylitol, and erythronate at fixed time intervals after administration with gas chromatography-mass spectrometry. We found: (i) a dose-dependent and saturable absorption of erythritol, (ii) a very low absorption of xylitol, (iii) a dose-dependent metabolization of erythritol into erythronate, and (iv) no metabolization of xylitol into erythronate. The implications of the metabolization of erythritol into erythronate for human health remain to be determined and more research in this area is needed. MDPI 2022-08-30 /pmc/articles/PMC9456049/ /pubmed/36077269 http://dx.doi.org/10.3390/ijms23179867 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bordier, Valentine
Teysseire, Fabienne
Senner, Frank
Schlotterbeck, Götz
Drewe, Jürgen
Beglinger, Christoph
Wölnerhanssen, Bettina K.
Meyer-Gerspach, Anne Christin
Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study
title Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study
title_full Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study
title_fullStr Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study
title_full_unstemmed Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study
title_short Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study
title_sort absorption and metabolism of the natural sweeteners erythritol and xylitol in humans: a dose-ranging study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456049/
https://www.ncbi.nlm.nih.gov/pubmed/36077269
http://dx.doi.org/10.3390/ijms23179867
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