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Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia

Periodontal disease is a frequent pathology worldwide, with a constantly increasing prevalence. For the optimal management of periodontal disease, there is a need to take advantage of actual technology to understand the bacterial etiology correlated with the pathogenic mechanisms, risk factors and t...

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Autores principales: Ursu, Ramona Gabriela, Iancu, Luminita Smaranda, Porumb-Andrese, Elena, Damian, Costin, Cobzaru, Roxana Gabriela, Nichitean, Giorgio, Ripa, Carmen, Sandu, Darius, Luchian, Ionut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456077/
https://www.ncbi.nlm.nih.gov/pubmed/36077312
http://dx.doi.org/10.3390/ijms23179915
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author Ursu, Ramona Gabriela
Iancu, Luminita Smaranda
Porumb-Andrese, Elena
Damian, Costin
Cobzaru, Roxana Gabriela
Nichitean, Giorgio
Ripa, Carmen
Sandu, Darius
Luchian, Ionut
author_facet Ursu, Ramona Gabriela
Iancu, Luminita Smaranda
Porumb-Andrese, Elena
Damian, Costin
Cobzaru, Roxana Gabriela
Nichitean, Giorgio
Ripa, Carmen
Sandu, Darius
Luchian, Ionut
author_sort Ursu, Ramona Gabriela
collection PubMed
description Periodontal disease is a frequent pathology worldwide, with a constantly increasing prevalence. For the optimal management of periodontal disease, there is a need to take advantage of actual technology to understand the bacterial etiology correlated with the pathogenic mechanisms, risk factors and treatment protocols. We analyzed the scientific literature published in the last 5 years regarding the recent applications of mRNA analysis in periodontal disease for the main known bacterial species considered to be the etiological agents: Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia. We identified new pathogenic mechanisms, therapeutic target genes and possible pathways to prevent periodontal disease. The mRNA analysis, as well as the important technological progress in recent years, supports its implementation in the routine management of periodontal disease patients.
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spelling pubmed-94560772022-09-09 Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia Ursu, Ramona Gabriela Iancu, Luminita Smaranda Porumb-Andrese, Elena Damian, Costin Cobzaru, Roxana Gabriela Nichitean, Giorgio Ripa, Carmen Sandu, Darius Luchian, Ionut Int J Mol Sci Review Periodontal disease is a frequent pathology worldwide, with a constantly increasing prevalence. For the optimal management of periodontal disease, there is a need to take advantage of actual technology to understand the bacterial etiology correlated with the pathogenic mechanisms, risk factors and treatment protocols. We analyzed the scientific literature published in the last 5 years regarding the recent applications of mRNA analysis in periodontal disease for the main known bacterial species considered to be the etiological agents: Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia. We identified new pathogenic mechanisms, therapeutic target genes and possible pathways to prevent periodontal disease. The mRNA analysis, as well as the important technological progress in recent years, supports its implementation in the routine management of periodontal disease patients. MDPI 2022-08-31 /pmc/articles/PMC9456077/ /pubmed/36077312 http://dx.doi.org/10.3390/ijms23179915 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ursu, Ramona Gabriela
Iancu, Luminita Smaranda
Porumb-Andrese, Elena
Damian, Costin
Cobzaru, Roxana Gabriela
Nichitean, Giorgio
Ripa, Carmen
Sandu, Darius
Luchian, Ionut
Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia
title Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia
title_full Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia
title_fullStr Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia
title_full_unstemmed Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia
title_short Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia
title_sort host mrna analysis of periodontal disease patients positive for porphyromonas gingivalis, aggregatibacter actinomycetemcomitans and tannerella forsythia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456077/
https://www.ncbi.nlm.nih.gov/pubmed/36077312
http://dx.doi.org/10.3390/ijms23179915
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