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Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia
Periodontal disease is a frequent pathology worldwide, with a constantly increasing prevalence. For the optimal management of periodontal disease, there is a need to take advantage of actual technology to understand the bacterial etiology correlated with the pathogenic mechanisms, risk factors and t...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456077/ https://www.ncbi.nlm.nih.gov/pubmed/36077312 http://dx.doi.org/10.3390/ijms23179915 |
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author | Ursu, Ramona Gabriela Iancu, Luminita Smaranda Porumb-Andrese, Elena Damian, Costin Cobzaru, Roxana Gabriela Nichitean, Giorgio Ripa, Carmen Sandu, Darius Luchian, Ionut |
author_facet | Ursu, Ramona Gabriela Iancu, Luminita Smaranda Porumb-Andrese, Elena Damian, Costin Cobzaru, Roxana Gabriela Nichitean, Giorgio Ripa, Carmen Sandu, Darius Luchian, Ionut |
author_sort | Ursu, Ramona Gabriela |
collection | PubMed |
description | Periodontal disease is a frequent pathology worldwide, with a constantly increasing prevalence. For the optimal management of periodontal disease, there is a need to take advantage of actual technology to understand the bacterial etiology correlated with the pathogenic mechanisms, risk factors and treatment protocols. We analyzed the scientific literature published in the last 5 years regarding the recent applications of mRNA analysis in periodontal disease for the main known bacterial species considered to be the etiological agents: Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia. We identified new pathogenic mechanisms, therapeutic target genes and possible pathways to prevent periodontal disease. The mRNA analysis, as well as the important technological progress in recent years, supports its implementation in the routine management of periodontal disease patients. |
format | Online Article Text |
id | pubmed-9456077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94560772022-09-09 Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia Ursu, Ramona Gabriela Iancu, Luminita Smaranda Porumb-Andrese, Elena Damian, Costin Cobzaru, Roxana Gabriela Nichitean, Giorgio Ripa, Carmen Sandu, Darius Luchian, Ionut Int J Mol Sci Review Periodontal disease is a frequent pathology worldwide, with a constantly increasing prevalence. For the optimal management of periodontal disease, there is a need to take advantage of actual technology to understand the bacterial etiology correlated with the pathogenic mechanisms, risk factors and treatment protocols. We analyzed the scientific literature published in the last 5 years regarding the recent applications of mRNA analysis in periodontal disease for the main known bacterial species considered to be the etiological agents: Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia. We identified new pathogenic mechanisms, therapeutic target genes and possible pathways to prevent periodontal disease. The mRNA analysis, as well as the important technological progress in recent years, supports its implementation in the routine management of periodontal disease patients. MDPI 2022-08-31 /pmc/articles/PMC9456077/ /pubmed/36077312 http://dx.doi.org/10.3390/ijms23179915 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ursu, Ramona Gabriela Iancu, Luminita Smaranda Porumb-Andrese, Elena Damian, Costin Cobzaru, Roxana Gabriela Nichitean, Giorgio Ripa, Carmen Sandu, Darius Luchian, Ionut Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia |
title | Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia |
title_full | Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia |
title_fullStr | Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia |
title_full_unstemmed | Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia |
title_short | Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia |
title_sort | host mrna analysis of periodontal disease patients positive for porphyromonas gingivalis, aggregatibacter actinomycetemcomitans and tannerella forsythia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456077/ https://www.ncbi.nlm.nih.gov/pubmed/36077312 http://dx.doi.org/10.3390/ijms23179915 |
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