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Insights into Allosteric Mechanisms of the Lung-Enriched p53 Mutants V157F and R158L

Lung cancer is a leading fatal malignancy in humans. p53 mutants exhibit not only loss of tumor suppressor capability but also oncogenic gain-of-function, contributing to lung cancer initiation, progression and therapeutic resistance. Research shows that p53 mutants V157F and R158L occur with high f...

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Detalles Bibliográficos
Autores principales:	Lei, Jiangtao, Li, Xuanyao, Cai, Mengqiang, Guo, Tianjing, Lin, Dongdong, Deng, Xiaohua, Li, Yin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456101/ https://www.ncbi.nlm.nih.gov/pubmed/36077492 http://dx.doi.org/10.3390/ijms231710100

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