Establishment and Characterization of Novel Human Intestinal In Vitro Models for Absorption and First-Pass Metabolism Studies

Commonly used intestinal in vitro models are limited in their potential to predict oral drug absorption. They either lack the capability to form a tight cellular monolayer mimicking the intestinal epithelial barrier or the expression of cytochrome P450 3A4 (CYP3A4). The aim of this study was to esta...

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Detalles Bibliográficos
Autores principales: Przybylla, Randy, Mullins, Christina Susanne, Krohn, Mathias, Oswald, Stefan, Linnebacher, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456142/
https://www.ncbi.nlm.nih.gov/pubmed/36077251
http://dx.doi.org/10.3390/ijms23179861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456142/
https://www.ncbi.nlm.nih.gov/pubmed/36077251
http://dx.doi.org/10.3390/ijms23179861

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