Cargando…

Establishment and Characterization of Novel Human Intestinal In Vitro Models for Absorption and First-Pass Metabolism Studies

Commonly used intestinal in vitro models are limited in their potential to predict oral drug absorption. They either lack the capability to form a tight cellular monolayer mimicking the intestinal epithelial barrier or the expression of cytochrome P450 3A4 (CYP3A4). The aim of this study was to esta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Przybylla, Randy, Mullins, Christina Susanne, Krohn, Mathias, Oswald, Stefan, Linnebacher, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456142/ https://www.ncbi.nlm.nih.gov/pubmed/36077251 http://dx.doi.org/10.3390/ijms23179861

Ejemplares similares

Novel In Vitro Models for Cell Differentiation and Drug Transport Studies of the Human Intestine
por: Przybylla, Randy, et al.
Publicado: (2023)

Microsatellite Status and IκBα Expression Levels Predict Sensitivity to Pharmaceutical Curcumin in Colorectal Cancer Cells
por: Lu, Lili, et al.
Publicado: (2022)

Establishment and Characterization of Primary Glioblastoma Cell Lines from Fresh and Frozen Material: A Detailed Comparison
por: Mullins, Christina Susanne, et al.
Publicado: (2013)

PKQuest: measurement of intestinal absorption and first pass metabolism – application to human ethanol pharmacokinetics
por: Levitt, David G
Publicado: (2002)

Human Colorectal Carcinoma Infiltrating B Lymphocytes Are Active Secretors of the Immunoglobulin Isotypes A, G, and M
por: Mullins, Christina Susanne, et al.
Publicado: (2019)

Intestinal Absorption and First-Pass Metabolism of Polyphenol Compounds in Rat and Their Transport Dynamics in Caco-2 Cells
por: Teng, Zenghui, et al.
Publicado: (2012)

Establishment and characterization of HROC69 – a Crohn´s related colonic carcinoma cell line and its matched patient-derived xenograft
por: Kuehn, Florian, et al.
Publicado: (2016)

Tumour-Derived Cell Lines and Their Potential for Therapy Prediction in Patients with Metastatic Colorectal Cancer
por: Wagner, Sandra, et al.
Publicado: (2021)

Integrated Biobanking and Tumor Model Establishment of Human Colorectal Carcinoma Provides Excellent Tools for Preclinical Research
por: Mullins, Christina S., et al.
Publicado: (2019)

Tumor Take Rate Optimization for Colorectal Carcinoma Patient-Derived Xenograft Models
por: Gock, Michael, et al.
Publicado: (2016)

Establishment, characterization, and drug screening of low-passage patient individual non-small cell lung cancer in vitro models including the rare pleomorphic subentity
por: Andus, Ingo, et al.
Publicado: (2023)

Global Association of Cause-specific Mortality between the Major Gastrointestinal Cancers and Parkinson’s Disease for the First Two Decades of the New Millennium
por: Lu, Lili, et al.
Publicado: (2022)

Optimized creation of glioblastoma patient derived xenografts for use in preclinical studies
por: William, Doreen, et al.
Publicado: (2017)

Dose-Dependent Pharmacokinetics of Tofacitinib in Rats: Influence of Hepatic and Intestinal First-Pass Metabolism
por: Lee, Ji Sang, et al.
Publicado: (2019)

Cancer-Cell-Derived IgG and Its Potential Role in Tumor Development
por: Kdimati, Said, et al.
Publicado: (2021)

Assessment of Bioavailability after In Vitro Digestion and First Pass Metabolism of Bioactive Peptides from Collagen Hydrolysates
por: Larder, Christina E., et al.
Publicado: (2021)

Generation, Characterization and Application of Antibodies Directed against HERV-H Gag Protein in Colorectal Samples
por: Mullins, Christina S., et al.
Publicado: (2016)

Determination of Site of Absorption of Propranolol in Rat Gut Using In Situ Single-Pass Intestinal Perfusion
por: Nagare, N., et al.
Publicado: (2010)

Intestinal absorption and metabolism of xenobiotics
por: Chhabra, Rajendra S.
Publicado: (1979)

Establishment, functional and genetic characterization of a colon derived large cell neuroendocrine carcinoma cell line
por: Gock, Michael, et al.
Publicado: (2018)

Intestine-Liver Axis On-Chip Reveals the Intestinal Protective Role on Hepatic Damage by Emulating Ethanol First-Pass Metabolism
por: De Gregorio, Vincenza, et al.
Publicado: (2020)

Pharmaceutical immunoglobulin G impairs anti-carcinoma activity of oxaliplatin in colon cancer cells
por: Shang, Yuru, et al.
Publicado: (2021)

HROP68: A rare case of medullary pancreatic cancer—characterization and chemosensitivity of the first patient-derived cell line
por: von den Driesch, Jens, et al.
Publicado: (2023)

A Non-Lipolysis Nanoemulsion Improved Oral Bioavailability by Reducing the First-Pass Metabolism of Raloxifene, and Related Absorption Mechanisms Being Studied
por: Ye, Jing-Yi, et al.
Publicado: (2020)

Establishment, functional and genetic characterization of three novel patient-derived rectal cancer cell lines
por: Gock, Michael, et al.
Publicado: (2018)

Site of Alcohol First-Pass Metabolism Among Women
por: Seyedsadjadi, Neda, et al.
Publicado: (2022)

The HROC-Xenobank—A High Quality Assured PDX Biobank of >100 Individual Colorectal Cancer Models
por: Matschos, Stephanie, et al.
Publicado: (2021)

THE ABSORPTION OF FAT BY INTESTINE OF GOLDEN HAMSTER IN VITRO
por: Strauss, Elliott W.
Publicado: (1963)

Analyzing non‐cancer causes of death of colorectal carcinoma patients in the US population for the years 2000–2016
por: Lu, Lili, et al.
Publicado: (2020)

Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats
por: López-Yerena, Anallely, et al.
Publicado: (2020)

Colorectal cancer vaccines: Tumor-associated antigens vs neoantigens
por: Wagner, Sandra, et al.
Publicado: (2018)

Mouse models of colorectal cancer: Past, present and future perspectives
por: Bürtin, Florian, et al.
Publicado: (2020)

Non-digestible stachyose promotes bioavailability of genistein through inhibiting intestinal degradation and first-pass metabolism of genistein in mice
por: Lu, Yalong, et al.
Publicado: (2017)

Triglyceride-mimetic prodrugs of scutellarin enhance oral bioavailability by promoting intestinal lymphatic transport and avoiding first-pass metabolism
por: Wang, Xinran, et al.
Publicado: (2021)

Optimizing the process of nucleofection for professional antigen presenting cells
por: Mullins, Christina Susanne, et al.
Publicado: (2015)

In-Depth Characterization of EpiIntestinal Microtissue as a Model for Intestinal Drug Absorption and Metabolism in Human
por: Cui, Yunhai, et al.
Publicado: (2020)

Message Passing and Metabolism
por: Parr, Thomas
Publicado: (2021)

AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro
por: Lange, Falko, et al.
Publicado: (2019)

Intestinal Permeability of Lamivudine Using Single Pass Intestinal Perfusion
por: Patel, J. R., et al.
Publicado: (2012)

Increased SEC23A Expression Correlates with Poor Prognosis and Immune Infiltration in Stomach Adenocarcinoma †
por: Zhaoran, Su, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_hkjthlospmea6ps2h6atlnshi7