Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Microglia from APOE Targeted Replacement Mice

The sex and APOE4 genotype are significant risk factors for Alzheimer’s disease (AD); however, the mechanism(s) responsible for this interaction are still a matter of debate. Here, we assess the responses of mixed-sex and sex-specific APOE3 and APOE4 primary microglia (PMG) to lipopolysaccharide and...

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Detalles Bibliográficos
Autores principales: Mhatre-Winters, Isha, Eid, Aseel, Han, Yoonhee, Tieu, Kim, Richardson, Jason R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456163/
https://www.ncbi.nlm.nih.gov/pubmed/36077227
http://dx.doi.org/10.3390/ijms23179829

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