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Role of Muscle LIM Protein in Mechanotransduction Process

The induction of protein synthesis is crucial to counteract the deconditioning of neuromuscular system and its atrophy. In the past, hormones and cytokines acting as growth factors involved in the intracellular events of these processes have been identified, while the implications of signaling pathw...

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Autores principales: Germain, Philippe, Delalande, Anthony, Pichon, Chantal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456170/
https://www.ncbi.nlm.nih.gov/pubmed/36077180
http://dx.doi.org/10.3390/ijms23179785
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author Germain, Philippe
Delalande, Anthony
Pichon, Chantal
author_facet Germain, Philippe
Delalande, Anthony
Pichon, Chantal
author_sort Germain, Philippe
collection PubMed
description The induction of protein synthesis is crucial to counteract the deconditioning of neuromuscular system and its atrophy. In the past, hormones and cytokines acting as growth factors involved in the intracellular events of these processes have been identified, while the implications of signaling pathways associated with the anabolism/catabolism ratio in reference to the molecular mechanism of skeletal muscle hypertrophy have been recently identified. Among them, the mechanotransduction resulting from a mechanical stress applied to the cell appears increasingly interesting as a potential pathway for therapeutic intervention. At present, there is an open question regarding the type of stress to apply in order to induce anabolic events or the type of mechanical strain with respect to the possible mechanosensing and mechanotransduction processes involved in muscle cells protein synthesis. This review is focused on the muscle LIM protein (MLP), a structural and mechanosensing protein with a LIM domain, which is expressed in the sarcomere and costamere of striated muscle cells. It acts as a transcriptional cofactor during cell proliferation after its nuclear translocation during the anabolic process of differentiation and rebuilding. Moreover, we discuss the possible opportunity of stimulating this mechanotransduction process to counteract the muscle atrophy induced by anabolic versus catabolic disorders coming from the environment, aging or myopathies.
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spelling pubmed-94561702022-09-09 Role of Muscle LIM Protein in Mechanotransduction Process Germain, Philippe Delalande, Anthony Pichon, Chantal Int J Mol Sci Review The induction of protein synthesis is crucial to counteract the deconditioning of neuromuscular system and its atrophy. In the past, hormones and cytokines acting as growth factors involved in the intracellular events of these processes have been identified, while the implications of signaling pathways associated with the anabolism/catabolism ratio in reference to the molecular mechanism of skeletal muscle hypertrophy have been recently identified. Among them, the mechanotransduction resulting from a mechanical stress applied to the cell appears increasingly interesting as a potential pathway for therapeutic intervention. At present, there is an open question regarding the type of stress to apply in order to induce anabolic events or the type of mechanical strain with respect to the possible mechanosensing and mechanotransduction processes involved in muscle cells protein synthesis. This review is focused on the muscle LIM protein (MLP), a structural and mechanosensing protein with a LIM domain, which is expressed in the sarcomere and costamere of striated muscle cells. It acts as a transcriptional cofactor during cell proliferation after its nuclear translocation during the anabolic process of differentiation and rebuilding. Moreover, we discuss the possible opportunity of stimulating this mechanotransduction process to counteract the muscle atrophy induced by anabolic versus catabolic disorders coming from the environment, aging or myopathies. MDPI 2022-08-29 /pmc/articles/PMC9456170/ /pubmed/36077180 http://dx.doi.org/10.3390/ijms23179785 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Germain, Philippe
Delalande, Anthony
Pichon, Chantal
Role of Muscle LIM Protein in Mechanotransduction Process
title Role of Muscle LIM Protein in Mechanotransduction Process
title_full Role of Muscle LIM Protein in Mechanotransduction Process
title_fullStr Role of Muscle LIM Protein in Mechanotransduction Process
title_full_unstemmed Role of Muscle LIM Protein in Mechanotransduction Process
title_short Role of Muscle LIM Protein in Mechanotransduction Process
title_sort role of muscle lim protein in mechanotransduction process
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456170/
https://www.ncbi.nlm.nih.gov/pubmed/36077180
http://dx.doi.org/10.3390/ijms23179785
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