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Loss of Protein Stability and Function Caused by P228L Variation in NADPH-Cytochrome P450 Reductase Linked to Lower Testosterone Levels

Cytochrome P450 oxidoreductase (POR) is the redox partner of steroid and drug-metabolising cytochromes P450 located in the endoplasmic reticulum. Mutations in POR cause a broad range of metabolic disorders. The POR variant rs17853284 (P228L), identified by genome sequencing, has been linked to lower...

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Detalles Bibliográficos
Autores principales:	Rojas Velazquez, Maria Natalia, Noebauer, Mathias, Pandey, Amit V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456303/ https://www.ncbi.nlm.nih.gov/pubmed/36077536 http://dx.doi.org/10.3390/ijms231710141

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