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Galectins: Important Regulators in Normal and Pathologic Pregnancies
Galectins (Gal) are characterized by their affinity for galactoside structures on glycoconjugates. This relationship is mediated by carbohydrate recognition domains, which are multifunctional regulators of basic cellular biological processes with high structural similarity among family members. They...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456357/ https://www.ncbi.nlm.nih.gov/pubmed/36077508 http://dx.doi.org/10.3390/ijms231710110 |
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author | Chen, Min Shi, Jia-Lu Zheng, Zi-Meng Lin, Zhi Li, Ming-Qing Shao, Jun |
author_facet | Chen, Min Shi, Jia-Lu Zheng, Zi-Meng Lin, Zhi Li, Ming-Qing Shao, Jun |
author_sort | Chen, Min |
collection | PubMed |
description | Galectins (Gal) are characterized by their affinity for galactoside structures on glycoconjugates. This relationship is mediated by carbohydrate recognition domains, which are multifunctional regulators of basic cellular biological processes with high structural similarity among family members. They participate in both innate and adaptive immune responses, as well as in reproductive immunology. Recently, the discovery that galectins are highly expressed at the maternal–fetal interface has garnerd the interest of experts in human reproduction. Galectins are involved in a variety of functions such as maternal–fetal immune tolerance, angiogenesis, trophoblast invasion and placental development and are considered to be important mediators of successful embryo implantation and during pregnancy. Dysregulation of these galectins is associated with abnormal and pathological pregnancies (e.g., preeclampsia, gestational diabetes mellitus, fetal growth restriction, preterm birth). Our work reviews the regulatory mechanisms of galectins in normal and pathological pregnancies and has implications for clinicians in the prevention, diagnosis and treatment of pregnancy-related diseases. |
format | Online Article Text |
id | pubmed-9456357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94563572022-09-09 Galectins: Important Regulators in Normal and Pathologic Pregnancies Chen, Min Shi, Jia-Lu Zheng, Zi-Meng Lin, Zhi Li, Ming-Qing Shao, Jun Int J Mol Sci Review Galectins (Gal) are characterized by their affinity for galactoside structures on glycoconjugates. This relationship is mediated by carbohydrate recognition domains, which are multifunctional regulators of basic cellular biological processes with high structural similarity among family members. They participate in both innate and adaptive immune responses, as well as in reproductive immunology. Recently, the discovery that galectins are highly expressed at the maternal–fetal interface has garnerd the interest of experts in human reproduction. Galectins are involved in a variety of functions such as maternal–fetal immune tolerance, angiogenesis, trophoblast invasion and placental development and are considered to be important mediators of successful embryo implantation and during pregnancy. Dysregulation of these galectins is associated with abnormal and pathological pregnancies (e.g., preeclampsia, gestational diabetes mellitus, fetal growth restriction, preterm birth). Our work reviews the regulatory mechanisms of galectins in normal and pathological pregnancies and has implications for clinicians in the prevention, diagnosis and treatment of pregnancy-related diseases. MDPI 2022-09-03 /pmc/articles/PMC9456357/ /pubmed/36077508 http://dx.doi.org/10.3390/ijms231710110 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chen, Min Shi, Jia-Lu Zheng, Zi-Meng Lin, Zhi Li, Ming-Qing Shao, Jun Galectins: Important Regulators in Normal and Pathologic Pregnancies |
title | Galectins: Important Regulators in Normal and Pathologic Pregnancies |
title_full | Galectins: Important Regulators in Normal and Pathologic Pregnancies |
title_fullStr | Galectins: Important Regulators in Normal and Pathologic Pregnancies |
title_full_unstemmed | Galectins: Important Regulators in Normal and Pathologic Pregnancies |
title_short | Galectins: Important Regulators in Normal and Pathologic Pregnancies |
title_sort | galectins: important regulators in normal and pathologic pregnancies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456357/ https://www.ncbi.nlm.nih.gov/pubmed/36077508 http://dx.doi.org/10.3390/ijms231710110 |
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