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Galectins: Important Regulators in Normal and Pathologic Pregnancies

Galectins (Gal) are characterized by their affinity for galactoside structures on glycoconjugates. This relationship is mediated by carbohydrate recognition domains, which are multifunctional regulators of basic cellular biological processes with high structural similarity among family members. They...

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Detalles Bibliográficos
Autores principales: Chen, Min, Shi, Jia-Lu, Zheng, Zi-Meng, Lin, Zhi, Li, Ming-Qing, Shao, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456357/
https://www.ncbi.nlm.nih.gov/pubmed/36077508
http://dx.doi.org/10.3390/ijms231710110
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author Chen, Min
Shi, Jia-Lu
Zheng, Zi-Meng
Lin, Zhi
Li, Ming-Qing
Shao, Jun
author_facet Chen, Min
Shi, Jia-Lu
Zheng, Zi-Meng
Lin, Zhi
Li, Ming-Qing
Shao, Jun
author_sort Chen, Min
collection PubMed
description Galectins (Gal) are characterized by their affinity for galactoside structures on glycoconjugates. This relationship is mediated by carbohydrate recognition domains, which are multifunctional regulators of basic cellular biological processes with high structural similarity among family members. They participate in both innate and adaptive immune responses, as well as in reproductive immunology. Recently, the discovery that galectins are highly expressed at the maternal–fetal interface has garnerd the interest of experts in human reproduction. Galectins are involved in a variety of functions such as maternal–fetal immune tolerance, angiogenesis, trophoblast invasion and placental development and are considered to be important mediators of successful embryo implantation and during pregnancy. Dysregulation of these galectins is associated with abnormal and pathological pregnancies (e.g., preeclampsia, gestational diabetes mellitus, fetal growth restriction, preterm birth). Our work reviews the regulatory mechanisms of galectins in normal and pathological pregnancies and has implications for clinicians in the prevention, diagnosis and treatment of pregnancy-related diseases.
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spelling pubmed-94563572022-09-09 Galectins: Important Regulators in Normal and Pathologic Pregnancies Chen, Min Shi, Jia-Lu Zheng, Zi-Meng Lin, Zhi Li, Ming-Qing Shao, Jun Int J Mol Sci Review Galectins (Gal) are characterized by their affinity for galactoside structures on glycoconjugates. This relationship is mediated by carbohydrate recognition domains, which are multifunctional regulators of basic cellular biological processes with high structural similarity among family members. They participate in both innate and adaptive immune responses, as well as in reproductive immunology. Recently, the discovery that galectins are highly expressed at the maternal–fetal interface has garnerd the interest of experts in human reproduction. Galectins are involved in a variety of functions such as maternal–fetal immune tolerance, angiogenesis, trophoblast invasion and placental development and are considered to be important mediators of successful embryo implantation and during pregnancy. Dysregulation of these galectins is associated with abnormal and pathological pregnancies (e.g., preeclampsia, gestational diabetes mellitus, fetal growth restriction, preterm birth). Our work reviews the regulatory mechanisms of galectins in normal and pathological pregnancies and has implications for clinicians in the prevention, diagnosis and treatment of pregnancy-related diseases. MDPI 2022-09-03 /pmc/articles/PMC9456357/ /pubmed/36077508 http://dx.doi.org/10.3390/ijms231710110 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Min
Shi, Jia-Lu
Zheng, Zi-Meng
Lin, Zhi
Li, Ming-Qing
Shao, Jun
Galectins: Important Regulators in Normal and Pathologic Pregnancies
title Galectins: Important Regulators in Normal and Pathologic Pregnancies
title_full Galectins: Important Regulators in Normal and Pathologic Pregnancies
title_fullStr Galectins: Important Regulators in Normal and Pathologic Pregnancies
title_full_unstemmed Galectins: Important Regulators in Normal and Pathologic Pregnancies
title_short Galectins: Important Regulators in Normal and Pathologic Pregnancies
title_sort galectins: important regulators in normal and pathologic pregnancies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456357/
https://www.ncbi.nlm.nih.gov/pubmed/36077508
http://dx.doi.org/10.3390/ijms231710110
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