Neuropathology of the Basal Ganglia in SNCA Transgenic Rat Model of Parkinson’s Disease: Involvement of Parvalbuminergic Interneurons and Glial-Derived Neurotropic Factor

Parkinson’s disease (PD) is a neurodegenerative disease characterized by the accumulation of alpha-synuclein, encoded by the SNCA gene. The main neuropathological hallmark of PD is the degeneration of dopaminergic neurons leading to striatal dopamine depletion. Trophic support by a neurotrophin call...

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Detalles Bibliográficos
Autores principales: Paldino, Emanuela, D’angelo, Vincenza, Massaro Cenere, Mariangela, Guatteo, Ezia, Barattucci, Simone, Migliorato, Giorgia, Berretta, Nicola, Riess, Olaf, Sancesario, Giuseppe, Mercuri, Nicola Biagio, Fusco, Francesca Romana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456397/
https://www.ncbi.nlm.nih.gov/pubmed/36077524
http://dx.doi.org/10.3390/ijms231710126

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