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Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer Therapy

Despite the great advancements made in cancer treatment, there are still many unsatisfied aspects, such as the wide palette of side effects and the drug resistance. There is an obvious increasing scientific attention towards nature and what it can offer the human race. Natural products can be used t...

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Autores principales: Sevastre, Ani-Simona, Manea, Elena Victoria, Popescu, Oana Stefana, Tache, Daniela Elise, Danoiu, Suzana, Sfredel, Veronica, Tataranu, Ligia Gabriela, Dricu, Anica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456420/
https://www.ncbi.nlm.nih.gov/pubmed/36077338
http://dx.doi.org/10.3390/ijms23179943
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author Sevastre, Ani-Simona
Manea, Elena Victoria
Popescu, Oana Stefana
Tache, Daniela Elise
Danoiu, Suzana
Sfredel, Veronica
Tataranu, Ligia Gabriela
Dricu, Anica
author_facet Sevastre, Ani-Simona
Manea, Elena Victoria
Popescu, Oana Stefana
Tache, Daniela Elise
Danoiu, Suzana
Sfredel, Veronica
Tataranu, Ligia Gabriela
Dricu, Anica
author_sort Sevastre, Ani-Simona
collection PubMed
description Despite the great advancements made in cancer treatment, there are still many unsatisfied aspects, such as the wide palette of side effects and the drug resistance. There is an obvious increasing scientific attention towards nature and what it can offer the human race. Natural products can be used to treat many diseases, of which some plant products are currently used to treat cancer. Plants produce secondary metabolites for their signaling mechanisms and natural defense. A variety of plant-derived products have shown promising anticancer properties in vitro and in vivo. Rather than recreating the natural production environment, ongoing studies are currently setting various strategies to significantly manipulate the quantity of anticancer molecules in plants. This review focuses on the recently studied secondary metabolite agents that have shown promising anticancer activity, outlining their potential mechanisms of action and pathways.
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spelling pubmed-94564202022-09-09 Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer Therapy Sevastre, Ani-Simona Manea, Elena Victoria Popescu, Oana Stefana Tache, Daniela Elise Danoiu, Suzana Sfredel, Veronica Tataranu, Ligia Gabriela Dricu, Anica Int J Mol Sci Review Despite the great advancements made in cancer treatment, there are still many unsatisfied aspects, such as the wide palette of side effects and the drug resistance. There is an obvious increasing scientific attention towards nature and what it can offer the human race. Natural products can be used to treat many diseases, of which some plant products are currently used to treat cancer. Plants produce secondary metabolites for their signaling mechanisms and natural defense. A variety of plant-derived products have shown promising anticancer properties in vitro and in vivo. Rather than recreating the natural production environment, ongoing studies are currently setting various strategies to significantly manipulate the quantity of anticancer molecules in plants. This review focuses on the recently studied secondary metabolite agents that have shown promising anticancer activity, outlining their potential mechanisms of action and pathways. MDPI 2022-09-01 /pmc/articles/PMC9456420/ /pubmed/36077338 http://dx.doi.org/10.3390/ijms23179943 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sevastre, Ani-Simona
Manea, Elena Victoria
Popescu, Oana Stefana
Tache, Daniela Elise
Danoiu, Suzana
Sfredel, Veronica
Tataranu, Ligia Gabriela
Dricu, Anica
Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer Therapy
title Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer Therapy
title_full Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer Therapy
title_fullStr Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer Therapy
title_full_unstemmed Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer Therapy
title_short Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer Therapy
title_sort intracellular pathways and mechanisms of colored secondary metabolites in cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456420/
https://www.ncbi.nlm.nih.gov/pubmed/36077338
http://dx.doi.org/10.3390/ijms23179943
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